Copyright © 1997 by the European Society of Cardiology.
© 1997 The European Society of Cardiology
Induction of subaortic septal ischaemia to reduce obstruction in hypertrophic obstructive cardiomyopathy
Studies to develop a new catheter-based concept of treatment
Department of Internal Medicine II—Cardiology Section, The Bielefeld Hospital, Academic Teaching Hospital of the University of Münster Bielefeld, Germany
Received 4 June 1996; accepted 19 August 1996.
Correspondence: Prof. Dr. med. H. Kuhn, Medizinische Klinik II—Schwerpunkt Kardiologie, Städtische Kliniken Bielefeld, Teutoburgerstr. 50, D - 33604 Bielefeld, Germany
Abstract
AIM: To develop a new catheter-based method of treatment in patients with hypertrophic obstructive cardiomyopathy.
METHOD: Does abolition of the blood supply to the subaortic part of the septum lead to regional myocardial ischaemia and a decrease in the left ventricular outflow tract gradient? To find this out, in 10 consecutive patients the first larger septal branch of the left anterior descending coronary artery was temporarily occluded with conventional percutaneous transluminal coronary angioplasty. The intracoronary electrocardiogram was registered for objective verification of the intended ischaemia. The intraventricular pressure was measured at rest and at the post extrasystolic beat under programmed electrostimulation of the right ventricle.
RESULTS: During occlusion, regional ischaemia was observed in all patients. Simultaneously, there was a significant reduction of the intraventricular gradient from 56·2 mmHg to 32·2 mmHg (P<0·05) followed by an increase from 32·2 mmHg to 61·1 mmHg (P<0·01) after release of occlusion of the septal branch. During ischaemia there was no increase in left ventricular end-diastolic pressure.
CONCLUSION: We conclude that the results form the basis for a new catheter interventional therapy in hypertrophic obstructive cardiomyopathy.
Key Words: Therapy of hypertrophic obstructive cardiomyopathy • catheter interventional therapy
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