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European Heart Journal 1997 18(8):1257-1260;
Copyright © 1997 by the European Society of Cardiology.
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© 1997 The European Society of Cardiology

Helicobacter pylori infection and coronary heart disease in the North Glasgow MONICA population

T. A. McDonagh*,, M. Woodward{dagger}, C. E. Morrison{ddagger}, J. J. V. McMurray*, H. Tunstall-Pedoe, G. D. O. Lowe||, K. E. L. McColl§ and H. J. Dargie*

*Department of Cardiology, Western Infirmary, Glasgow and MRC Clinical Initiative in Heart Failure, University of Glasgow Glasgow
{dagger}Department of Applied Statistics, University of Reading Glasgow
{ddagger}Scottish MONICA Project Glasgow
¶Cardiovascular Epidemiology Unit, University of Dundee, Ninewells Hospital Dundee, Scotland, U.K.
||Department of Medicine, Glasgow Royal Infirmary Dundee, Scotland, U.K.
§Department of Medicine and Therapeutics, Western Infirmary Glasgow

Received 17 December 1996; accepted 18 December 1996.

Correspondence: Dr T. A. McDonagh, Department of Cardiology, Western Infirmary, 11 Dumbarton Road, Glasgow G11 6NT, Scotland, U.K.

Abstract

AIM: Recent evidence suggests that Helicobacter pylori infection is associated with coronary heart disease. We investigated whether H. Pylori infection is related to prevalent coronary heart disease, in a random sample of 1428 men and women aged 25–74 years.

METHODS AND RESULTS: Coronary heart disease was assessed by questionnaire and electrocardiography (ECG). Standard risk factors for coronary heart disease, fibrinogen concentration and serum concentrations of H. pylori-specific IgG antibody were measured. H. pylori seropositivity increased with age (P≤0·001) and was significantly more prevalent in men than women. H. pylori infection was associated with current smoking and a higher systolic blood pressure in men but not in women. There was no significant increase in the odds ratio in those seropositive for H. pylori with regard to any manifestation of coronary heart disease, after adjustment for age, standard cardiovascular risk factors and social class. Likewise, age-adjusted plasma fibrinogen was no higher in seropositives.

CONCLUSION: Seropositivity to H. pylori is associated with a trend towards a greater prevalence of coronary heart disease. However, that association is likely to be spurious and can be adequately explained by the much stronger association of H. pylori infection with age and social class, both of which are linked with coronary heart disease.

Key Words: Helicobacter pylori • heart disease • epidemiology • MONICA Project


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