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European Heart Journal 1997 18(8):1313-1321;
Copyright © 1997 by the European Society of Cardiology.
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© 1997 The European Society of Cardiology

Beneficial effect of enalapril on left ventricular remodelling in patients with a severe residual stenosis after acute anterior wall infarction

L. H. B. Baur, J. J. Schipperheyn, E. E. van der Wall, E. A. van der Velde*, M. J. Schalij, B. L. F. van Eck-Smit{dagger}, A. van der Laarse, P. J. Voogd, M. I. Sedney{ddagger}, J. H. C. Reiber{dagger} and A. V. G. Bruschke

Department of Cardiology, Leiden University Medical Center The Netherlands
*Department of Medical Statistics, Leiden University Medical Center The Netherlands
{dagger}Department of Nuclear Medicine, Leiden University Medical Center The Netherlands
{ddagger}Department of Cardiology, Bronovo Hospital The Hague, The Netherlands

Received 6 March 1997; accepted 14 March 1997.

Correspondence: Ernst E. van der Wall, MD, FESC, Department of Cardiology, Leiden University Medical Center, Building 1, C5-P25, 2333 AA Leiden, The Netherlands

Abstract

OBJECTIVE: The present study was designed to evaluate the effects of early angiotensin converting enzyme (ACE) inhibition on left ventricular enlargement in patients with anterior wall infarction following reperfusion therapy.

METHODS: Seventy-one consecutive patients with an anterior wall myocardial infarction were randomly allocated to enalapril (n=36) or placebo (n=35). All patients received either thrombolytic therapy (n=46) or underwent primary coronary angioplasty (n=25). Medication was started within 48 h admission to hospital and continued for 48 weeks. The process of left ventricular remodelling was assessed with two-dimensional echocardiography at 3 weeks and 1 year after the acute onset, and was related to the severity of the residual stenosis of the infarct-related artery.

RESULTS: Baseline left ventricular ejection fraction was 39·2±8·7%. During the study period, left ventricular end-diastolic volume index increased from 48·2±9·9 ml. m–2 to 54·6±12·2 ml. m–2 at 3 weeks, and to 59·4±170 ml. m–2 after 1 year in control patients (P<0·001). In the enalapril-treated patients, left ventricular end-diastolic volume index increased from 50·0±16·1 to 57·7±19·3 ml. m–2 at 3 weeks, and to 61·9±22·7 ml. m–2 after 1 year (P<0·001). Both at 3 weeks and after 1 year, no overall differences in left ventricular volumes were observed between the enalapril and the placebo group (both ns). However, patients with a residual stenosis severity of ≥70% in the infarct-related artery (n=43) showed significant attenuation of remodelling by enalapril (n=22) when compared to placebo (n=21). In patients on enalapril, left ventricular end-diastolic volume index increased from 470±130 to 53·7±17·7 ml. m–2 compared to 48·0±9·6 to 60·3±16·3 ml . m–2 in control patients (P<0·03). Also diastolic filling parameters were significantly improved in patients with ≥70% residual stenosis.

CONCLUSION: In patients with an anterior wall infarction and a severe residual infarct-related coronary artery stenosis following reperfusion, treatment with enalapril prevents the process of left ventricular remodelling. As left ventricular dilatation is an early process we suggest that treatment with ACE inhibition should be started as soon as possible in this group of patients.

Key Words: Myocardial infarction • remodelling • coronary angioplasty • thrombolysis • enalapril


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