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European Heart Journal 1997 18(Supplement A):51-55; doi:10.1093/eurheartj/18.suppl_A.51
Copyright © 1997 by the European Society of Cardiology.
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© 1997 The European Society of Cardiology

Microcirculation: What is the role of calcium antagonists?

P. G. Camici

MRC Clinical Sciences centre and Royal Postgraduate Medical School, Harnmersmith Hospital London, U.K.

Correspondence: Prof Paolo G. Camici, MRC Clinical Sciences Centre, Hammersmith Hospital, London W12 0NN, U.K

This review article discusses some of the potentially beneficial effects of calcium antagonists on the coronary microcirculation. These include their vasodilating action on coronary resistance vessels as well as their effects on extravascular resistance (i.e. intramyocardial pressure).

Examples are presented of how the non-invasive measurement of myocardial blood flow and flow reserve by means of positron emission tomography can contribute to the understanding of the effects of drug treatment on the coronary microcirculation.

The action of calcium antagonists on the coronary microcirculation may help explain the efficacy of these drugs against ischaemia and ischaemia-reperfusion damage.

Key Words: Coronary microcirculation • myocardial blood flow • myocardial ischaemia • calcium antagonists • positron emission tomography


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