Skip Navigation

European Heart Journal 1997 18(Supplement A):8-14; doi:10.1093/eurheartj/18.suppl_A.8
Copyright © 1997 by the European Society of Cardiology.
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Sumeray, M. S.
Right arrow Articles by Yellon, D. M.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Sumeray, M. S.
Right arrow Articles by Yellon, D. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1997 The European Society of Cardiology

Myocardial preconditioning

What have we learned?

M. S. Sumeray and D. M. Yellon

The Hatter Institute, Department of Academic and Clinical Cardiology, University College Hospital London, U.K.

Correspondence: Professor D. M. Yellon, The Hatter Institute, Department of Academic and Clinical Cardiology, University College Hospital, Grafton Way, London WCIE 6DB, U.K

It is now 10 years since the phenomenon termed ‘ischaemic preconditioning’ was formally recognised. The possibility that an innate mechanism of myocardial protection might be inducible in the human heart has generated considerable excitement and enthusiastic research. This has led to a more detailed understanding of the mechanisms underlying ischaemia-reperfusion injury and has provided reason to believe that the progress of myocardial necrosis might be modified by invoking a protective adaptation within the myocyte. Considerable progress has been made towards the identification of cell triggers and transduction mechanisms that may be involved in the process of preconditioning. It is likely that future studies will examine the effect of several classes of pharmacological agents that may prove capable of mimicking the protective effect of sub-lethal ischaemia.

Key Words: Ischaemia • ischaemia-reperfusion injury • myocardium • preconditioning • second window of protection


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
N.-P. Wang, B. L. Bufkin, M. Nakamura, Z.-Q. Zhao, J. N. Wilcox, K. O. Hewan-Lowe, R. A. Guyton, and J. Vinten-Johansen
Ischemic preconditioning reduces neutrophil accumulation and myocardial apoptosis
Ann. Thorac. Surg., June 1, 1999; 67(6): 1689 - 1695.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.