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European Heart Journal 1997 18(Supplement A):80-86; doi:10.1093/eurheartj/18.suppl_A.80
Copyright © 1997 by the European Society of Cardiology.
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© 1997 The European Society of Cardiology

Calcium antagonists and atherosclerosis

Experimental evidence

A. L. Catapano

Institute of Pharmacological Sciences, University of Milano and Centro per lo Studio delle Vasculopatie Periferiche Ospedale Bassini, Milano, Italy

Correspondence: Prof. Alberico L. Catapano, Institute of Pharmacological Sciences, Via Balzaretti, 9, 20133 Milano, Italy

Accumulation of cholesterol and calcium is the hallmark of atherosclerosis. Ca2+ antagonists lessen the severity of experimentally induced atherosclerosis in a variety of animal models, including hypercholesterolaemic animals. They also reduce cholesterol accumulation in the arterial wall, but without affecting plasma lipids. This review briefly discusses in vitro and in vivo experimental studies on the anti-atherosclerotic properties of Ca2+ antagonists and outlines mechanisms by which these compounds affect cellular lipid metabolism.

Key Words: Lipids • lipoprotein • LDL • LDL-receptor • cholesterol • ACAT


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