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European Heart Journal 1997 18(Supplement F):2-10; doi:10.1093/eurheartj/18.suppl_F.2
Copyright © 1997 by the European Society of Cardiology.
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© 1997 The European Society of Cardiology

The GUSTO trial and the open artery theory

R. M. Califf

Duke Clinical Research Institute, Division of Cardiology, Department of Medicine, Duke University Medical Center Durham, North Carolina, U.S.A.

Correspondence: Robert M. Califf, MD, Duke Clinical Research Institute, 2024 West Main Street, Durham, NC 27705, U.S.A.

The GUSTO trials have provided continuing insight into the complexities of a simple fundamental relationship: early and sustained coronary perfusion in patients with acute myocardial infarction leads to lower mortality and morbidity. To a large extent, the GUSTO trials have attempted to develop approaches to therapy that will ensure the highest early rate of reperfusion with the least risk. A table provides a summary of the completed trials and those that are planned in attempts to provide further knowledge in the continuing quest to improve the plight of patients with acute myocardial infarction.

Key Words: Acute myocardial infarction • open artery theory • thrombolytic agents • the GUSTO trial


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