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European Heart Journal 1998 19(11):1657-1665; doi:10.1053/euhj.1998.1097
Copyright © 1998 by the European Society of Cardiology.
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Angiotensin II type 1 receptor A1166C gene polymorphism

Absence of an association with the risk of coronary artery disease and myocardial infarction and of a synergistic effect with angiotensin-converting enzyme gene polymorphism on the risk of these diseases

A. Gardemanna, Q.D. Nguyena, J. Hummea, J. Strickera, N. Katza, H. Tillmannsb, F.W. Hehrleinc, M. Raud and W. Haberboschd

a Institut für Klinische Chemie und Pathobiochemie, Giessen
b Abteilung Kardiologie und Angiologie, Giessen
c Klinik für Herz- und Gefäßchirurgie der Justus-Liebig-Universität Giessen, Giessen
d Max-Planck-Institut für Experimentelle und Klinische Forschung, Kerckhoff-Klinik, Bad Nauheim, Germany

accepted March 30, 1998

Aim

There is evidence that interaction between angiotensin II type 1 receptor A1166C gene polymorphism and angio-tensin I-converting enzyme Insertion/Deletion gene variation might have an effect on the risk of myocardial infarction. The study was carried out in a population of 2244 male Caucasians, whose coronary anatomy was defined by means of coronary angiography. We analysed the relationship, on the risk of ischaemic heart disease, of angiotensin II type 1 receptor A1166C gene variation, not only to myocardial infarction but also to coronary artery disease, and its potential interaction with angio-tensin I-converting enzyme Insertion/Deletion gene polymorphism.

Methods and Results

No association was detected between angiotensin II type 1 receptor A1166C gene polymorphism and coronary artery disease. Similarly, there was no link to myocardial infarction, either in the total population or in low risk groups. In addition, most importantly, we found no interaction between angiotensin II type 1 receptor A1166C gene variation and angiotensin I-converting Insertion/Deletion polymorphism, either in connection with the risk of coronary artery disease or myocardial infarction.

Conclusion

This angiotensin II type 1 receptor A1166C gene variation is not associated with any detectable increase in risk of ischaemic heart disease. The findings of the present study do not suggest that, as regards risk of coronary artery disease and myocardial infarction, there is interaction between gene polymorphism and angiotensin I-converting enzyme Insertion/Deletion gene variation.The European Society of Cardiology

Key Words: Angiotensin II type 1 receptor A1166C gene polymorphism • angiotensin I-converting enzyme Insertion/Deletion gene polymorphism • cardiovascular disease • myocardial infarction • risk factors • renin–angiotensin–aldosterone system

Correspondence: Andreas Gardemann, Institut für Klinische Chemie und Pathobiochemie, Klinikum der Justus-Liebig-Universität Gießen, Gaffky-Strasse 11, 35392 Gießen, Germany.


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