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European Heart Journal 1998 19(2):319-325; doi:10.1053/euhj.1997.0587
Copyright © 1998 by the European Society of Cardiology.
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Donor ACE gene polymorphism: a genetic risk factor for accelerated coronary sclerosis following cardiac transplantation

D.A. Cunningham, S.J. Crisp, M. Barbir, F. Lazem, M.J. Dunn and M.H. Yacoub

Division of Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, London, U.K.
Heart Science Centre, Harefield Hospital, Harefield, Middlesex, U.K.

accepted May 30, 1997

Aims

To investigate the role of angiotensin converting enzyme (ACE) (I/D) gene polymorphism in the development of coronary sclerosis after cardiac transplantation.

Methods and results

Eighty cardiac transplant recipients (44 transplant associated coronary artery disease; 36 non-transplant associated coronary artery disease) and their donors were genotyped by polymerase chain reaction. The allele frequencies of the recipients in the transplant associated coronary artery disease and non-transplant associated coronary artery disease groups (I=0·47 and 0·48, D=0·53 and 0·52, respectively) did not differ significantly between the groups. However, there was a negative association between the frequency of the I allele in the donor and the development of transplant associated coronary artery disease. The D allele in the donor population of the non-transplant associated coronary artery disease group had a significantly (P<0·01) lower frequency (0·35) than either the transplant associated coronary artery disease group (0·53) or that of the general population (0·57). Other factors analysed were recipient family history, cholesterol levels, age, sex and body mass index, donor age and acute rejection, of which the significant (P<0·05) factors were acute rejection and sex of the recipient.

Conclusion

These results suggest that the ACE genotype of the donor organ may be an additional risk factor for the development of coronary artery disease following cardiac transplantation and that tissue rather than circulating ACE could be implicated in the pathogenesis of this disease.

Key Words: Angiotensin • genes • arteriosclerosis • transplantation

Correspondence: Professor Magdi H. Yacoub, Department of Cardiothoracic Surgery, National Heart and Lung Institute, Heart Science Centre, Harefield Hospital, Harefield, Middlesex UB9 6JH, U.K.


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