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European Heart Journal 1998 19(7):1109-1117; doi:10.1053/euhj.1998.0155
Copyright © 1998 by the European Society of Cardiology.
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Variants of renin–angiotensin system genes and echocardiographic left ventricular mass

H Kaumaabf1, M Ikäheimoa, M.J Savolainenab, KiemaT.-R b, A.O Rantalaab, M Liljaab, A Reunanenc and Y.A Kesäniemiab

a Department of Internal Medicine, University of Oulu, Oulu
b Department of Biocenter Oulu, University of Oulu, Oulu
c National Public Health Institute, Helsinki, Finland

Received February 10, 1998; accepted February 25, 1998

Aims

Variants of renin–angiotensin system genes are shown to be associated with cardiovascular pathology. The association between renin–angiotensin system genes and left ventricular mass was investigated in a population-based case-control study.

Methods and Results

The association between echocardiographic left ventricular mass and both insertion/deletion polymorphism of the angiotensin-converting enzyme gene and the methionine|adthreonine variant at position 235 of the angiotensinogen gene was studied in a random cohort of 430 hypertensive and 426 control subjects. No differences in the adjusted left ventricular mass values between the different genotypes were seen among either the hypertensive or the control subjects, whether men or women, or in the subgroups of normotensive or physically active subjects. Gene variation had no statistically significant synergistic effect on left ventricular mass values. In control women, the deletion allele of the angiotensin-converting enzyme gene was associated with an increased risk of left ventricular hypertrophy. However, this finding was based on a small number of women with left ventricular hypertrophy and should be interpreted with caution.

Conclusion

Variations in renin–angiotensin system genes had no major effect on left ventricular mass in this middle-aged population-based cohort of hypertensives and control subjects.

Key Words: Angiotensin • angiotensin-converting enzyme • genetics • ventricular hypertrophy

f1 Correspondence: Heikki Kauma, MD, Department of Internal Medicine, University of Oulu, Kajaanintie 50, FIN-90220 Oulu, Finland.


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