Skip Navigation

European Heart Journal 1981 2(1):41-48;
Copyright © 1981 by the European Society of Cardiology.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by MERILLON, J. P.
Right arrow Articles by GPIRGON, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by MERILLON, J. P.
Right arrow Articles by GPIRGON, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1981, by The European Society Of Cardiology

The left ventricular end-systolic pressure-volume ratio. Studies during changes in load and inotropism in the human

J. P. MERILLON, F. NEUKIRCU, G. MOTTE, M. C. AUMOUNT, N. D. CURIEN, R. PRASQUIER and R. GPIRGON

Hoüpital Reaujon, 100 Bd du Geèneèrul Lecterc, 92118 Clichy Cedex France

Received 24 March 1980; revised 22 October 1980; .

Requests for reprints to: J P. Merillon, Service de Cardiologie, Hoüpital Beaujon, 100 Bd du Geèneèral Leclerc, 92118 Clichy Cedex France

Abstract

Ascending aortic pressures and left ventricular volumes were measured simultaneously in 65 patients in the basal state and during changes:(1)in load by sodium nitroprusside (n = 21) or by angiotensin (n = 6), (2) in inotropism by post-extra-systolic potentiation (PESP)(n = 18) and increase in heart rate (atrial pacing)(n = 20). Thirty patients had normal hearts (group I), 35 had or had had the symptoms left ventricular failure complicating the course of an idiopathic cardiomyopathy (group II). All were in sinus rhythm. The slope of the end-systolic pressure (ESP)—end-systolic volume (ESV) relationship (ETS) and the ESP/ESV. ratio (EES) were greater in group I than in group II. There was no difference between ETS and EES. EES discriminated the normal patients from those with cardiomyopathy as well as (dp/dt) max, [dp/dt)/Pt] max, EF or VCF. In the two groups, EES was independent of loading changes. This ratio increased after post-extra-systolic potentiation and during atrial pacing. Two findings in patients with ventricular failure were unexplained: (1) in 1/3 of the patients EES did not correspond to the maximum value of the instantaneous pressure-volume ratio: (2)the Vd was higher in group II than in group I and close to 48 ml.

Key Words: Cardiomyopathy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.