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European Heart Journal 1981 2(2):123-126;
Copyright © 1981 by the European Society of Cardiology.
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© 1981, by The European Society Of Cardiology

The effect of beta2adrenergic blockade on serum potassium and glucose levels during open heart surger

M. C. PETCH, R. MCKAY and D. W. BETHUNE

Regional Cardothoracic Unit, Papworth Hospital Cambridge CB3 8RE, U.K.

Received 25 June 1980; revised 14 November 1980; .

Requests for reprints to: M. C.Petch, MD MRCP, Regional Cardiac Unit, Papworth Hospital, Cambride CB3 8RE U.K.

Abstract

Changes in serum potassium and glucose levels during cardiopuimonary bypass were studied in 20 ± patients undergoing coronary artery bypass surgery. Ten had previously been treated with propranolol and 10 with metoprolol using mean daily dosages of 244 and 215 mg respectively. In the propranolol group there was a mean rise in serum potassium of l.13 mmol7/l (P= <0.01) whereas there was no significant. change in the metoprolol group. In both groups there was an initial rise in blood glucose which remained elevated in the propranolol group but fell towards normal in the metoprolol group. Metabolic changes due to beta1 adrenergic blockade are not generally recognized but may have profound clinical significance in some patients.

Key Words: Propranolol • metoprolol • coronary artery bypass surgery • cardioplegia.


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[Abstract] [PDF]


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