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European Heart Journal 1981 2(2):127-133;
Copyright © 1981 by the European Society of Cardiology.
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© 1981, by The European Society Of Cardiology

Treatment of refractory heart failure with trimazosin

D. J. E. TAYLOR and A. J. BELL

Cardiology Department, Kent and Canterbury Hospital Canterbury CTI 3NG Kent, U.K.

Received 25 August 1980; revised 14 November 1980; .

Requests for reprints to: Dr D.J.E. Taylor, FRCP, Consultant Cardiologist. Hent and Canterbury Hospital, Canterbury CTI 3NG. Kent. U.K.

Abstract

Seven patients with severe heart failure resistant to conventional treatment with digoxin and diuretics were given trimazosin, a new mixed arterial and venous vasodilator. There was a mean 31% fall in left ventricular filling pressure (P > 0.005) and a mean 25% rise in cardiac index (P> 0.05). One patient failed to respond. In three patients these haemodynamic changes resulted in excellent clinical and radiological improvement which was maintained for months. No side-effects were found.

Oral trimazosin is a long-acting effective mixed vasodilator which improves left ventricular function in patients with chronic resistant left ventricular failure.

Key Words: Vasodilator • trimazosin • heart failure


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