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European Heart Journal 1981 2(2):139-146;
Copyright © 1981 by the European Society of Cardiology.
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© 1981, by The European Society Of Cardiology

Ergonovine maleate test in various anginal syndromes

A. MARESTA, A. CAPUCCI, A. MARZOCCHI, R. M. FERRETTI, R. PERTICUCCI and B. MAGNANI

Department of Cardiology, University of Bologna Italy

Received 24 September 1980; .

Requests for reprints to: Aleardo Maresta. MD, Istituto di Cardiologia Dell' Universitaè di Bologna, Via Massarentin, 9, 40138 Bologna, Italy

Abstract

The ergonovine maleate (EM) test has been performed in four groups of 10 patients each: (A) variant angina; (B) angina at rest with ST segment depression during pain; (C) effort angina; (D) atypical chest i pain.

EM was injected i.v. (highest dose 0-4 mg) first in the Coronary Care Unit and thereafter during coronary angiography. EM caused coronary spasm with angina and ST segment elevation in every patient of group A and in one patient of group B.

In five and four patients of groups B and C, respectively, EM induced angina and ST segment depression without any localized coronary spasm, the coronary angiography showing only a diffuse narrowing of the coronary vessels; these patients had the lowest effort tolerance and the most severe coronary lesions.

Spontaneous or induced coronary spasm in patients with angina at rest and ST segment depression during chest pain did not occur in this study. An increase of the peripheral and/or coronary resistances due to EM could be the mechanism of the ischemic attack in patients with severe coronary lesions.

Key Words: Ergonovine test • angina • coronary spasm


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