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European Heart Journal 1981 2(5):365-373;
Copyright © 1981 by the European Society of Cardiology.
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© 1981, by The European Society Of Cardiology

Smoking, blood pressure and serum cholesterol as risk factors of acute myocardial infaction and death among men in Eastern Finland

J. T. SALONEN*,{dagger},, P. PUSKA*,{ddagger} and T. E. KOTTKE§

*North Karelia Project, University of Kuopio Box 40, 70101 Kuopio 10, Finland
{dagger}Research Institute of Public Health, University of Kuopio Box 138, 70101 Kuopio 10, finland
{ddagger}Epidemiological Research Unit, Public Health Laboratory of Finland Mannerheimintie 166, 00280 Helsinki 28, Finland
§Laboratory of Physiological Hygiene, School of Public Health, University of Minnesota Minneapolis, U.S.A

Received 7 November 1980; revised 26 March 1981; .

Dr Jukka T. Salonen, North Karelia Project, University of Kuopio, Box 40, 70101 Kuopio 10, Finland

Abstract

The impact of smoking, serum cholesterol and blood pressure on the risk of acute myocardial infarction and death due to all causes and cardiovascular diseases was studied in a random sample of men aged 35 to 59 years from the North Karelia and Kuopio counties of Eastern Finland. This is an area with an exceptionally high incidence of coronary heart disease. Altogether, 4034 men were studied with a participation rate of 92%. These men were followed-up with a myocardial infarction register and death certificate data. During the first five years 256 deaths occurred among all subjects. There were 66 acute myocardial infarctions in the North Karelian men reporting no recent coronary heart disease. Smoking, elevated serum cholesterol and blood pressure were independently and jointly related to an increased risk of acute myocardial infarction and death due to all causes and to cardiovascular disease. Smokers had a 2–3-fold age-adjusted risk of acute myocardial infarction, a 2-2-fold risk of any death and a 2.1-fold risk of cardiovascular death compared with non-smokers. The age-adjusted risk ratios for systolic blood pressure of 160 mm Hg or more were 1.3, 1.4 and 1.9 and those for serum cholesterol at least 8 mmol/l (309 mg/100 ml) 2.6, 1.5 and 2.6 concerning myocardial infarction, all deaths and cardiovascular deaths, respectively. All risk ratios except that of systolic blood pressure for acute myocardial infarction were significant at levels of at least P < 0.05

Key Words: Ischaemic heart disease • longitudinal studies • smoking • blood • blood pressure • blood cholesterol


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