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European Heart Journal 1999 20(10):764-770; doi:10.1053/euhj.1998.1400
Copyright © 1999 by the European Society of Cardiology.
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QT dispersion in patients with arrhythmogenic right ventricular dysplasia

M. Bennf1, P.S. Hansen and A.K. Pedersen

Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark

revised October 26, 1998; accepted October 28, 1998

Abstract

Aims Arrhythmogenic right ventricular dysplasia is a rarely diagnosed cardiomyopathy, but a frequent cause of ventricular arrhythmia and sudden cardiac death. QT interval dispersion, measured as an interlead variability of QT, is a marker of dispersion of ventricular repolarization and, hence, of electrical instability. The present study was conducted to assess the occurrence of QT dispersion and its modulation during treatment with sotalol.

Methods Twenty-five patients with the diagnosis of arrhythmogenic right ventricular dysplasia were studied retrospectively. Fourteen patients were considered low risk for malignant ventricular arrhythmia and sudden cardiac death, and 11 high risk due to documented sustained ventricular arrhythmia, cardiac arrest, or sudden cardiac death. Twenty five healthy volunteers served as control subjects.

Results Dispersion of repolarization was significantly higher in patients than in control subjects (QTd and JTd:P<0·05). Dispersion of repolarization was equal in patients both with and without malignant arrhythmias. There was no significant change in dispersion after treatment with sotalol. Adjacent QT dispersion between leads V3–V4, V4–V5and V5–V6, respectively, was higher in patients than in control subjects (P<0·05), while no differences were seen in leads V1–V2and V2–V3.

Conclusion QT interval dispersion is increased in patients with arrhythmogenic right ventricular dysplasia. However, the degree of dispersion is not related to the severity of symptoms, nor is it influenced by treatment with sotalol.

Key Words: Arrhythmogenic right ventricular cardiomyopathy • cardiomyopathy • electrocardiography • sudden death • sotalol

f1 Correspondence: Marianne Benn, MD, Department of Cardiology, Research Unit, Aarhus University Hospital, Brendstrupgaardsvej, 8000 Aarhus N, Denmark.


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