Copyright © 2000 by the European Society of Cardiology.
Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials
revised October 22, 2000; accepted October 4, 2000
Abstract
Aims Three randomized trials of implantable cardioverter defibrillator (ICD) therapy vs medical treatment for the prevention of death in survivors of ventricular fibrillation or sustained ventricular tachycardia have been reported with what might appear to be different results. The present analysis was performed to obtain the most precise estimate of the efficacy of the ICD, compared to amiodarone, for prolonging survival in patients with malignant ventricular arrhythmia.
Methods and Results Individual patient data from the Antiarrhythmics vs Implantable Defibrillator (AVID) study, the Cardiac Arrest Study Hamburg (CASH) and the Canadian Implantable Defibrillator Study (CIDS) were merged into a master database according to a pre-specified protocol. Proportional hazard modelling of individual patient data was used to estimate hazard ratios and to investigate subgroup interactions. Fixed effect meta-analysis techniques were also used to evaluate treatment effects and to assess heterogeneity across studies. The classic fixed effects meta-analysis showed that the estimates of ICD benefit from the three studies were consistent with each other (P heterogeneity=0·306). It also showed a significant reduction in death from any cause with the ICD; with a summary hazard ratio (ICD:amiodarone) of 0·72 (95% confidence interval 0·60, 0·87;P=0·0006). For the outcome of arrhythmic death, the hazard ratio was 0·50 (95% confidence interval 0·37, 0·67;P<0·0001). Survival was extended by a mean of 4·4 months by the ICD over a follow-up period of 6 years. Patients with left ventricular ejection fraction 
35% derived significantly more benefit from ICD therapy than those with better preserved left ventricular function. Patients treated before the availability of non-thoracotomy ICD implants derived significantly less benefit from ICD therapy than those treated in the non-thoracotomy era.
Conclusion Results from the three trials of the ICD vs amiodarone are consistent with each other. There is a 28% reduction in the relative risk of death with the ICD that is due almost entirely to a 50% reduction in arrhythmic death.
Key Words: Amiodarone, implantable cardioverter defibrillator, meta-analysis, cardiac arrest, ventricular tachycardia
f1 Correspondence: Stuart J. Connolly, MD, Hamilton Health Sciences Corporation, Hamilton General Site, 237 Barton Street East, Hamilton, ON L8L 2X2, Canada.
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|
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|
 |
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|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 A. Al-Sayegh, A. M. Shukkur, and M. Akbar Automatic Implantable Cardioverter Defibrillator for the Treatment of Ventricular Fibrillation Following Coronary Artery Spasm: A Case Report Angiology, February 1, 2007; 58(1): 122 - 125. [Abstract] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 P. M. Seferovic, A. D. Ristic, R. Maksimovic, D. S. Simeunovic, G. G. Ristic, G. Radovanovic, D. Seferovic, B. Maisch, and M. Matucci-Cerinic Cardiac arrhythmias and conduction disturbances in autoimmune rheumatic diseases Rheumatology, October 1, 2006; 45(suppl_4): iv39 - iv42. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Developed in Collaboration With the European Heart, D. P. Zipes, A. J. Camm, M. Borggrefe, A. E. Buxton, B. Chaitman, M. Fromer, G. Gregoratos, G. Klein, A. J. Moss, et al. ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) J. Am. Coll. Cardiol., September 5, 2006; 48(5): 1064 - 1108. [Full Text] [PDF]
|
|
|
|
|
|
Developed in Collaboration With the European Heart, D. P. Zipes, A. J. Camm, M. Borggrefe, A. E. Buxton, B. Chaitman, M. Fromer, G. Gregoratos, G. Klein, A. J. Moss, et al. ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) J. Am. Coll. Cardiol., September 5, 2006; 48(5): e247 - e346. [Full Text] [PDF]
|
|
|
|
|
|
D. P. Zipes, D. P. Zipes, A. J. Camm, M. Borggrefe, A. E. Buxton, B. Chaitman, M. Fromer, G. Gregoratos, G. Klein, A. J. Moss, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death--executive summary: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Eur. Heart J., September 1, 2006; 27(17): 2099 - 2140. [Full Text] [PDF]
|
|
|
|
|
|
Writing Committee Members, D. P. Zipes, A. J. Camm, M. Borggrefe, A. E. Buxton, B. Chaitman, M. Fromer, G. Gregoratos, G. Klein, A. J. Moss, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: A report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death) Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society Europace, September 1, 2006; 8(9): 746 - 837. [Full Text] [PDF]
|
|
|
|
|
|
G. Klein, C. Lissel, A.-C. Fuchs, A. Gardiwal, H. Oswald, M. deSousa, A. M. Pichlmaier, R. Lichtinghagen, H. Geerlings, P. Lippolt, et al. Predictors of VT/VF-occurrence in ICD patients: results from the PROFIT-Study. Europace, August 1, 2006; 8(8): 618 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Hohnloser, P. Dorian, R. Roberts, M. Gent, C. W. Israel, E. Fain, J. Champagne, and S. J. Connolly Effect of Amiodarone and Sotalol on Ventricular Defibrillation Threshold: The Optimal Pharmacological Therapy in Cardioverter Defibrillator Patients (OPTIC) Trial Circulation, July 11, 2006; 114(2): 104 - 109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Chan, K. Stein, T. Chow, M. Fendrick, J. T. Bigger, and S. Vijan Cost-Effectiveness of a Microvolt T-Wave Alternans Screening Strategy for Implantable Cardioverter-Defibrillator Placement in the MADIT-II-Eligible Population J. Am. Coll. Cardiol., July 4, 2006; 48(1): 112 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-H. Kuck and S. Nisam ICD therapy: 'the sickest benefit the most...': what about the less sick? Europace, July 1, 2006; 8(7): 508 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Goldberger and R. Lampert Implantable Cardioverter-Defibrillators: Expanding Indications and Technologies JAMA, February 15, 2006; 295(7): 809 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Connolly Use and Misuse of Surrogate Outcomes in Arrhythmia Trials Circulation, February 14, 2006; 113(6): 764 - 766. [Full Text] [PDF]
|
|
|
|
|
|
J. P. Pell, M. Corstorphine, A. McConnachie, N. L. Walker, J. C. Caldwell, A. K. Marsden, N. R. Grubb, and S. M. Cobbe Post-discharge survival following pre-hospital cardiopulmonary arrest due to cardiac aetiology: temporal trends and impact of changes in clinical management Eur. Heart J., February 2, 2006; 27(4): 406 - 412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Herlitz Post-discharge survival following pre-hospital cardiopulmonary arrest owing to cardiac aetiology Eur. Heart J., February 2, 2006; 27(4): 377 - 378. [Full Text] [PDF]
|
|
|
|
 |
|
 M C S Hall and D M Todd Modern management of arrhythmias Postgrad. Med. J., February 1, 2006; 82(964): 117 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Connolly, P. Dorian, R. S. Roberts, M. Gent, S. Bailin, E. S. Fain, K. Thorpe, J. Champagne, M. Talajic, B. Coutu, et al. Comparison of {beta}-Blockers, Amiodarone Plus {beta}-Blockers, or Sotalol for Prevention of Shocks From Implantable Cardioverter Defibrillators: The OPTIC Study: A Randomized Trial JAMA, January 11, 2006; 295(2): 165 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Krahn, M. Gollob, R. Yee, L. J. Gula, A. C. Skanes, B. D. Walker, and G. J. Klein Diagnosis of Unexplained Cardiac Arrest: Role of Adrenaline and Procainamide Infusion Circulation, October 11, 2005; 112(15): 2228 - 2234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A.M.J. Theuns, A. S. Thornton, A. P. J. Klootwijk, M. F. Scholten, P. J.M.J. Vantrimpont, A. H.M.M. Balk, and L. J. Jordaens Outcome in patients with an ICD incorporating cardiac resynchronisation therapy: Differences between primary and secondary prophylaxis Eur J Heart Fail, October 1, 2005; 7(6): 1027 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kadish and M. Mehra Heart Failure Devices: Implantable Cardioverter-Defibrillators and Biventricular Pacing Therapy Circulation, June 21, 2005; 111(24): 3327 - 3335. [Full Text] [PDF]
|
|
|
|
 |
|
 M. C Simmonds, J. P T Higginsa, L. A Stewartb, J. F Tierneyb, M. J Clarke, and S. G Thompson Meta-analysis of individual patient data from randomized trials: a review of methods used in practice Clinical Trials, June 1, 2005; 2(3): 209 - 217. [Abstract] [PDF]
|
|
|
|
|
|
A. E. Buxton, A. J. Moss, A. E. Buxton, and A. J. Moss Should everyone with an ejection fraction less than or equal to 30% receive an implantable cardioverter-defibrillator? Circulation, May 17, 2005; 111(19): 2537 - 2549. [Full Text] [PDF]
|
|
|
|
|
|
A Y Patwala and D J Wright Device based treatment of heart failure Postgrad. Med. J., May 1, 2005; 81(955): 286 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Desai, J. C. Fang, W. H. Maisel, and K. L. Baughman Implantable Defibrillators for the Prevention of Mortality in Patients With Nonischemic Cardiomyopathy: A Meta-analysis of Randomized Controlled Trials JAMA, December 15, 2004; 292(23): 2874 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Dorian, M. Borggrefe, H. R. Al-Khalidi, S. H. Hohnloser, J. M. Brum, D. S. Tatla, J. Brachmann, R. J. Myerburg, D. S. Cannom, M. van der Laan, et al. Placebo-Controlled, Randomized Clinical Trial of Azimilide for Prevention of Ventricular Tachyarrhythmias in Patients With an Implantable Cardioverter Defibrillator Circulation, December 14, 2004; 110(24): 3646 - 3654. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Hohnloser, K. H. Kuck, P. Dorian, R. S. Roberts, J. R. Hampton, R. Hatala, E. Fain, M. Gent, S. J. Connolly, and the DINAMIT Investigators Prophylactic Use of an Implantable Cardioverter-Defibrillator after Acute Myocardial Infarction N. Engl. J. Med., December 9, 2004; 351(24): 2481 - 2488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Davis and A. S.L. Tang Implantable cardioverter defibrillators: therapy against Canada's leading killer Can. Med. Assoc. J., October 26, 2004; 171(9): 1037 - 1038. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 G. Nichol, P. Kaul, E. Huszti, and J. F.P. Bridges Cost-Effectiveness of Cardiac Resynchronization Therapy in Patients with Symptomatic Heart Failure Ann Intern Med, September 7, 2004; 141(5): 343 - 351. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
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F. Bokhari, D. Newman, M. Greene, V. Korley, I. Mangat, and P. Dorian Long-Term Comparison of the Implantable Cardioverter Defibrillator Versus Amiodarone: Eleven-Year Follow-Up of a Subset of Patients in the Canadian Implantable Defibrillator Study (CIDS) Circulation, July 13, 2004; 110(2): 112 - 116. [Abstract] [Full Text] [PDF]
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C. D. Swerdlow Reappraisal of implant testing of implantable cardioverter defibrillators J. Am. Coll. Cardiol., July 7, 2004; 44(1): 92 - 94. [Full Text] [PDF]
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R. Cappato, S. Boczor, K.-H. Kuck, and on behalf of the CASH Investigators Response to programmed ventricular stimulation and clinical outcome in cardiac arrest survivors receiving randomised assignment to implantable cardioverter defibrillator or antiarrhythmic drug therapy Eur. Heart J., April 2, 2004; 25(8): 642 - 649. [Abstract] [Full Text] [PDF]
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 R Gradaus, C Wollmann, J Kobe, D Hammel, S Kotthoff, M Block, G Breithardt, and D Bocker Potential benefit from implantable cardioverter-defibrillator therapy in children and young adolescents Heart, March 1, 2004; 90(3): 328 - 329. [Full Text] [PDF]
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A. Quesada, J.ús Almendral, F. Arribas, R. Ricci, C. Wolpert, P. Adragao, E. Cobo, X. Navarro, and on behalf DATAS investigators The DATAS rationale and design: a controlled, randomized trial to assess the clinical benefit of dual chamber (DDED) defibrillator Europace, January 1, 2004; 6(2): 142 - 150. [Abstract] [Full Text] [PDF]
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E.W. Lau, M.J. Griffith, R.K. Pathmanathan, G.A. Ng, M.M. Clune, J. Cooper, H.J. Marshall, P.R. Forsey, P.J. Stafford, R.G. Gray, et al. The midlands trial of empirical amiodarone versus electrophysiology-guided interventions and implantable cardioverter-defibrillators (MAVERIC): a multi-centre prospective randomised clinical trial on the secondary prevention of sudden cardiac death Europace, January 1, 2004; 6(4): 257 - 266. [Abstract] [Full Text] [PDF]
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J. P. DiMarco Implantable Cardioverter-Defibrillators N. Engl. J. Med., November 6, 2003; 349(19): 1836 - 1847. [Full Text] [PDF]
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G. Nichol, T. Valenzuela, D. Roe, L. Clark, E. Huszti, and G.A. Wells Cost Effectiveness of Defibrillation by Targeted Responders in Public Settings Circulation, August 12, 2003; 108(6): 697 - 703. [Abstract] [Full Text] [PDF]
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 T. Houghton and G. C Kaye Implantable devices for treating tachyarrhythmias BMJ, August 9, 2003; 327(7410): 333 - 336. [Full Text] [PDF]
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G. Boriani, M. Biffi, C. Martignani, C. Camanini, F. Grigioni, C. Rapezzi, and A. Branzi Cardioverter-defibrillators after MADIT-II: the balance between weight of evidence and treatment costs Eur J Heart Fail, August 1, 2003; 5(4): 419 - 425. [Abstract] [Full Text] [PDF]
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J. V. Jayachandran and D. P. Zipes Say no to primary prophylaxis with implantable cardioverter-defibrillators in asymptomatic nonischemic dilated cardiomyopathy? J. Am. Coll. Cardiol., May 21, 2003; 41(10): 1713 - 1715. [Full Text] [PDF]
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D. S. Lee, L. D. Green, P. P. Liu, P. Dorian, D. M. Newman, F. C. Grant, J. V. Tu, and D. A. Alter Effectiveness of implantable defibrillators for preventing arrhythmic events and death: A Meta-Analysis J. Am. Coll. Cardiol., May 7, 2003; 41(9): 1573 - 1582. [Abstract] [Full Text] [PDF]
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 P K Moulik, M N Attar, E L Rose, and A A Khaleeli Successful resuscitation of a patient with electrical storm Emerg. Med. J., May 1, 2003; 20(3): e4 - 4. [Abstract] [Full Text] [PDF]
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P. C. Deedwania The Key to Unraveling the Mystery of Mortality in Heart Failure: An Integrated Approach Circulation, April 8, 2003; 107(13): 1719 - 1721. [Full Text] [PDF]
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J. A. Ezekowitz, P. W. Armstrong, and F. A. McAlister Implantable Cardioverter Defibrillators in Primary and Secondary Prevention: A Systematic Review of Randomized, Controlled Trials Ann Intern Med, March 18, 2003; 138(6): 445 - 452. [Abstract] [Full Text] [PDF]
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 Using oral amiodarone DTB, February 1, 2003; 41(2): 9 - 12. [Abstract] [Full Text] [PDF]
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M. L. Weisfeldt and L. B. Becker Resuscitation After Cardiac Arrest: A 3-Phase Time-Sensitive Model JAMA, December 18, 2002; 288(23): 3035 - 3038. [Full Text] [PDF]
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S. Yusuf and B. Pitt A Lifetime of Prevention: The Case of Heart Failure Circulation, December 10, 2002; 106(24): 2997 - 2998. [Full Text] [PDF]
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J. M Morgan PATIENTS WITH VENTRICULAR ARRHYTHMIAS: WHO SHOULD BE REFERRED TO AN ELECTROPHYSIOLOGIST? Heart, December 1, 2002; 88(5): 544 - 550. [Full Text] [PDF]
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S Z Abildstrom, C Rask-Madsen, M M Ottesen, P K Andersen, S Rosthoj, C Torp-Pedersen, and L Kober Impact of age and sex on sudden cardiovascular death following myocardial infarction Heart, December 1, 2002; 88(6): 573 - 578. [Abstract] [Full Text] [PDF]
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A. Maisel B-Type Natriuretic Peptide Levels: Diagnostic and Prognostic in Congestive Heart Failure: What's Next? Circulation, May 21, 2002; 105(20): 2328 - 2331. [Full Text] [PDF]
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R. Berger, M. Huelsman, K. Strecker, A. Bojic, P. Moser, B. Stanek, and R. Pacher B-Type Natriuretic Peptide Predicts Sudden Death in Patients With Chronic Heart Failure Circulation, May 21, 2002; 105(20): 2392 - 2397. [Abstract] [Full Text] [PDF]
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S. Nisam and J. Farre Is prophylaxis the best use of the ICD? Eur. Heart J., May 1, 2002; 23(9): 700 - 705. [Full Text] [PDF]
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J Parkes, J Bryant, and R Milne Implantable cardioverter-defibrillators in arrhythmias: a rapid and systematic review of effectiveness Heart, May 1, 2002; 87(5): 438 - 442. [Abstract] [Full Text] [PDF]
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C Stellbrink, A.-M Sinha, B Diem, A Auricchio, S Boccanelli, J Brugada, H Klein, J Morgan, L Padeletti, E Aliot, et al. Implantable card ioverter-defibrillators with or without cardiac resynchronization therapy -- multiple therapy in a single device: a review with special reference to the PACIVIAN study Eur. Heart J. Suppl., April 1, 2002; 4(suppl_D): D88 - D94. [Abstract] [PDF]
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