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European Heart Journal 2000 21(4):327-333; doi:10.1053/euhj.1999.1956
Copyright © 2000 by the European Society of Cardiology.
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Is there a place for the late cardioversion of atrial fibrillation?. A long-term follow-up study of patients with post-thyrotoxic atrial fibrillation

H Nakazawaa, D.A Lythallb, J Nohc, N Ishikawac, K Suginoc, K Itoc and S.M.C Hardmand,f1

a Department of Physiology, Tokai University Medical School, Japan
b Kent & Canterbury & St Thomas' Hospitals, U.K.
c Ito Hospital, Tokyo, Japan
d University College London Medical School and the UCL and Whittington Hospitals, London, U.K.

revised June 7, 1999; accepted June 9, 1999

Abstract

Aims As atrial fibrillation is associated with significant mortality and morbidity, restoration of sinus rhythm is desirable. However, previous data suggest that cardioversion should be restricted to patients in whom the fibrillation is of limited duration (<1–2 years) because of high relapse rates. It may be the frequent association with cardiac disease, rather than the duration of fibrillation itself, which determined the high relapse of earlier studies. The aim of this study was to investigate rates of cardioversion, maintenance of sinus rhythm and predictors of subsequent relapse in a homogeneous group of patients without evidence of any co-existent cardiac disease.

Methods and Results We report on a retrospective series of 106 patients with thyrotoxicosis-induced fibrillation but no other heart disease: 87% had been in atrial fibrillation for >12 months (median duration 28·5, interquartile range 15–47 months). Cardioversion was attempted using disopyramide and then electric shock. Ninety-eight patients were successfully cardioverted: at late follow-up, 80·6±37 months (mean±SD), 67% were in sinus rhythm.

Conclusion Although a relationship between the duration of fibrillation and maintenance of sinus rhythm was found, the high proportion remaining in sinus rhythm, compared with other series, suggests this influence may be less important than the presence or absence of structural heart disease.

Key Words: Longstanding atrial fibrillation, cardioversion, maintenance of sinus rhythm, disopyramide

f1 Correspondence: Dr S. M. C. Hardman, Clinical & Academic Department of Cardiovascular Medicine, University College London Medical School (Whittington Campus), St Mary's Wing, Whittington Hospital, Highgate Hill, London N19 5NF, U.K.


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