Copyright © 2001 by the European Society of Cardiology.
The human G-protein ß3 subunit C825T polymorphism is associated with coronary artery vasoconstriction
a Service d'Epidémiologie et de Santé Publique-INSERM U.508, Institut Pasteur de Lille, Lille Cedex, France
b Service de Cardiologie B et Hémodynamique, Hôpital Cardiologique, Lille, France
c Département de Cardiologie, Hôpital Universitaire de Caen, Côte de Nacre, France
d Centre Hospitalier et Universitaire de Lille, Lille, France
revised July 25, 2000; accepted July 26, 2000
Abstract
Aims Abnormal coronary vasomotion plays a role in the clinical expression of coronary artery disease. We hypothesized that the functional C825T polymorphism located in the ubiquitous G-protein ß3 subunit, implicated in the cellular signal transduction of many receptors, could modify artery coronary vasomotion. We assessed the potential association of the pertussis toxin-sensitive G protein ß3 subunit (GNB3) gene C825T polymorphism on coronary vasomotion in humans.
Methods and Results We examined the response of angiographically normal human coronary arteries (n=131) after intravenous injection of methylergonovine maleate, a vasoconstrictor, followed by injection of isosorbide dinitrate, a vasodilator, according to GNB3 genotypes. Coronary vasomotion was assessed with quantitative coronary angiography. Subjects bearing at least one T allele had greater susceptibility to vasoconstriction in response to methylergonovine maleate than CC subjects, whereas vasodilation in response to isosorbide dinitrate did not differ among the different genotypes.
Conclusion The C825T polymorphism of the G-protein ß3 subunit may be a genetic determinant of coronary artery vasomotion in humans.
Key Words: Genetic polymorphism, G-protein ß3 subunit, coronary artery vasomotion
f1 Correspondence: Pr. Philippe Amouyel, Service d'Epidémiologie et de Santé Publique, INSERM U.508, Institut Pasteur de Lille, 1 rue Calmette, BP 245, 59019 Lille Cedex, France.
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