Copyright © 2001 by the European Society of Cardiology.
Particulate air pollution is associated with an acute phase response in men. Results from the MONICA–Augsburg Study
a GSF-National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
b Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Ulm, Germany
c Department of Medicine, Royal Free and University College Medical School, London, U.K.
revised September 22, 2000; accepted October 4, 2000
Abstract
Aims Episodes of increased air pollution are associated with increases in hospital admissions for cardiovascular disease. Even modest acute phase responses are associated with increased risk of coronary heart disease. The study investigates whether induction of an acute phase response by exposure to air pollution may contribute to cardiovascular pathology.
Methods and Results A prospective cohort study based on a survey in 1984/85 with a 3-year follow-up was conducted in 631 randomly selected men aged 45 to 64 years free of cardiovascular disease at entry 1984/85. Serum C-reactive protein concentrations were determined by a high sensitivity immunoradiometric assay. C-reactive protein concentration was increased in association with the 1985 air pollution episode. In multivariate analyses, elevated concentrations were independently associated with concentrations of total suspended particles and the sulphur dioxide episode. At ambient concentrations of pollution, as noted during the 1985 air pollution episode, the odds of observing C-reactive protein concentrations above 5·7mg.l–1(>90th percentile) tripled, and increases of 26µg.m–3total suspended particles (mean of 5 days) raised the odds of C-reactive protein levels 50% above the 90th percentile.
Conclusions Exposure to current levels of particulate matter in the atmosphere elicits an acute phase response in randomly selected healthy middle-aged men, which may contribute to the increased cardiovascular risk caused by air pollution.
Key Words: Acute phase reaction, air pollution, cardiovascular disease, epidemiology, risk factors
f1 Correspondence: Annette Peters, National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Postfach 1129, 85758 Oberschleissheim, Germany.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Baccarelli, R. O. Wright, V. Bollati, L. Tarantini, A. A. Litonjua, H. H. Suh, A. Zanobetti, D. Sparrow, P. S. Vokonas, and J. Schwartz Rapid DNA Methylation Changes after Exposure to Traffic Particles Am. J. Respir. Crit. Care Med., April 1, 2009; 179(7): 572 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Z. Simkhovich, M. T. Kleinman, and R. A. Kloner Air Pollution and Cardiovascular Injury: Epidemiology, Toxicology, and Mechanisms J. Am. Coll. Cardiol., August 26, 2008; 52(9): 719 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M S O'Neill, A V Diez-Roux, A H Auchincloss, T G Franklin, D R Jacobs Jr, B C Astor, J T Dvonch, and J Kaufman Airborne particulate matter exposure and urinary albumin excretion: the Multi-Ethnic Study of Atherosclerosis Occup. Environ. Med., August 1, 2008; 65(8): 534 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. G. Tankersley, H. C. Champion, E. Takimoto, K. Gabrielson, D. Bedja, V. Misra, H. El-Haddad, R. Rabold, and W. Mitzner Exposure to inhaled particulate matter impairs cardiac function in senescent mice Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R252 - R263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tornqvist, N. L. Mills, M. Gonzalez, M. R. Miller, S. D. Robinson, I. L. Megson, W. MacNee, K. Donaldson, S. Soderberg, D. E. Newby, et al. Persistent Endothelial Dysfunction in Humans after Diesel Exhaust Inhalation Am. J. Respir. Crit. Care Med., August 15, 2007; 176(4): 395 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Peel, K. B. Metzger, M. Klein, W. D. Flanders, J. A. Mulholland, and P. E. Tolbert Ambient Air Pollution and Cardiovascular Emergency Department Visits in Potentially Sensitive Groups Am. J. Epidemiol., March 15, 2007; 165(6): 625 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Ritz, J. Wan, and D. Diaz-Sanchez Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L33 - L39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Pope III, J. B. Muhlestein, H. T. May, D. G. Renlund, J. L. Anderson, and B. D. Horne Ischemic Heart Disease Events Triggered by Short-Term Exposure to Fine Particulate Air Pollution Circulation, December 5, 2006; 114(23): 2443 - 2448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zanobetti and J. Schwartz Air pollution and emergency admissions in Boston, MA. J Epidemiol Community Health, October 1, 2006; 60(10): 890 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Maitre, V. Bonneterre, L. Huillard, P. Sabatier, and R. de Gaudemaris Impact of urban atmospheric pollution on coronary disease Eur. Heart J., October 1, 2006; 27(19): 2275 - 2284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zeka, J. R Sullivan, P. S Vokonas, D. Sparrow, and J. Schwartz Inflammatory markers and particulate air pollution: characterizing the pathway to disease Int. J. Epidemiol., October 1, 2006; 35(5): 1347 - 1354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Peters Commentary: Inflamed about ultrafine particles? Int. J. Epidemiol., October 1, 2006; 35(5): 1355 - 1356. [Full Text] [PDF]
|
|
|
|
|
|
A. V. Diez Roux, A. H. Auchincloss, B. Astor, R. G. Barr, M. Cushman, T. Dvonch, D. R. Jacobs Jr., J. Kaufman, X. Lin, and P. Samson Recent Exposure to Particulate Matter and C-reactive Protein Concentration in the Multi-Ethnic Study of Atherosclerosis Am. J. Epidemiol., September 1, 2006; 164(5): 437 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Cozzi, S. Hazarika, H. W. Stallings III, W. E. Cascio, R. B. Devlin, R. M. Lust, C. J. Wingard, and M. R. Van Scott Ultrafine particulate matter exposure augments ischemia-reperfusion injury in mice Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H894 - H903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ruckerl, A. Ibald-Mulli, W. Koenig, A. Schneider, G. Woelke, J. Cyrys, J. Heinrich, V. Marder, M. Frampton, H. E. Wichmann, et al. Air Pollution and Markers of Inflammation and Coagulation in Patients with Coronary Heart Disease Am. J. Respir. Crit. Care Med., February 15, 2006; 173(4): 432 - 441. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H C Routledge, S Manney, R M Harrison, J G Ayres, and J N Townend Effect of inhaled sulphur dioxide and carbon particles on heart rate variability and markers of inflammation and coagulation in human subjects Heart, February 1, 2006; 92(2): 220 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Sun, A. Wang, X. Jin, A. Natanzon, D. Duquaine, R. D. Brook, J.-G. S. Aguinaldo, Z. A. Fayad, V. Fuster, M. Lippmann, et al. Long-term Air Pollution Exposure and Acceleration of Atherosclerosis and Vascular Inflammation in an Animal Model JAMA, December 21, 2005; 294(23): 3003 - 3010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Forastiere, M. Stafoggia, S. Picciotto, T. Bellander, D. D'Ippoliti, T. Lanki, S. von Klot, F. Nyberg, P. Paatero, A. Peters, et al. A Case-Crossover Analysis of Out-of-Hospital Coronary Deaths and Air Pollution in Rome, Italy Am. J. Respir. Crit. Care Med., December 15, 2005; 172(12): 1549 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Zeka, A Zanobetti, and J Schwartz Short term effects of particulate matter on cause specific mortality: effects of lags and modification by city characteristics Occup. Environ. Med., October 1, 2005; 62(10): 718 - 725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rajagopalan, Q. Sun, and L. C. Chen Particulate Pollution and Endothelial Function: Deja Vu All Over Again in the Air Circulation, June 7, 2005; 111(22): 2869 - 2871. [Full Text] [PDF]
|
|
|
|
|
|
M. S. O'Neill, A. Veves, A. Zanobetti, J. A. Sarnat, D. R. Gold, P. A. Economides, E. S. Horton, and J. Schwartz Diabetes Enhances Vulnerability to Particulate Air Pollution-Associated Impairment in Vascular Reactivity and Endothelial Function Circulation, June 7, 2005; 111(22): 2913 - 2920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M Finkelstein, M. Jerrett, and M. R Sears Environmental inequality and circulatory disease mortality gradients J Epidemiol Community Health, June 1, 2005; 59(6): 481 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J N Townend The way to dusty death? Thorax, June 1, 2005; 60(6): 441 - 442. [Full Text] [PDF]
|
|
|
|
|
|
J Y Kim, J-C Chen, P D Boyce, and D C Christiani Exposure to welding fumes is associated with acute systemic inflammatory responses Occup. Environ. Med., March 1, 2005; 62(3): 157 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P S Gilmour, E R Morrison, M A Vickers, I Ford, C A Ludlam, M Greaves, K Donaldson, and W MacNee The procoagulant potential of environmental particles (PM10) Occup. Environ. Med., March 1, 2005; 62(3): 164 - 171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Peters, S. von Klot, M. Heier, I. Trentinaglia, A. Hormann, H. E. Wichmann, H. Lowel, and the Cooperative Health Research in the Region of A Exposure to Traffic and the Onset of Myocardial Infarction N. Engl. J. Med., October 21, 2004; 351(17): 1721 - 1730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Zanobetti, M. J. Canner, P. H. Stone, J. Schwartz, D. Sher, E. Eagan-Bengston, K. A. Gates, L. H. Hartley, H. Suh, and D. R. Gold Ambient Pollution and Blood Pressure in Cardiac Rehabilitation Patients Circulation, October 12, 2004; 110(15): 2184 - 2189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.E. Sharman, J.R. Cockcroft, and J.S. Coombes Cardiovascular implications of exposure to traffic air pollution during exercise QJM, October 1, 2004; 97(10): 637 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. DeMeo, A. Zanobetti, A. A. Litonjua, B. A. Coull, J. Schwartz, and D. R. Gold Ambient Air Pollution and Oxygen Saturation Am. J. Respir. Crit. Care Med., August 15, 2004; 170(4): 383 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Brook, B. Franklin, W. Cascio, Y. Hong, G. Howard, M. Lipsett, R. Luepker, M. Mittleman, J. Samet, S. C. Smith Jr, et al. Air Pollution and Cardiovascular Disease: A Statement for Healthcare Professionals From the Expert Panel on Population and Prevention Science of the American Heart Association Circulation, June 1, 2004; 109(21): 2655 - 2671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Riediker, W. E. Cascio, T. R. Griggs, M. C. Herbst, P. A. Bromberg, L. Neas, R. W. Williams, and R. B. Devlin Particulate Matter Exposure in Cars Is Associated with Cardiovascular Effects in Healthy Young Men Am. J. Respir. Crit. Care Med., April 15, 2004; 169(8): 934 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Schwartz Air Pollution and Children's Health Pediatrics, April 1, 2004; 113(4/S1): 1037 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G Adamkiewicz, S Ebelt, M Syring, J Slater, F E Speizer, J Schwartz, H Suh, and D R Gold Association between air pollution exposure and exhaled nitric oxide in an elderly population Thorax, March 1, 2004; 59(3): 204 - 209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bhatnagar Cardiovascular pathophysiology of environmental pollutants Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H479 - H485. [Full Text] [PDF]
|
|
|
|
|
|
C. A. Pope III, R. T. Burnett, G. D. Thurston, M. J. Thun, E. E. Calle, D. Krewski, and J. J. Godleski Cardiovascular Mortality and Long-Term Exposure to Particulate Air Pollution: Epidemiological Evidence of General Pathophysiological Pathways of Disease Circulation, January 6, 2004; 109(1): 71 - 77. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H C Routledge, J G Ayres, and J N Townend Why cardiologists should be interested in air pollution Heart, December 1, 2003; 89(12): 1383 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Koenig C-reactive protein and cardiovascular risk: an update on what is going on in cardiology Nephrol. Dial. Transplant., June 1, 2003; 18(6): 1039 - 1041. [Full Text] [PDF]
|
|
|
|
 |
|
 R.B. Devlin, A.J. Ghio, H. Kehrl, G. Sanders, and W. Cascio Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability Eur. Respir. J., May 1, 2003; 21(40_suppl): 76S - 80s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Verrier, M. A. Mittleman, and P. H. Stone Air Pollution: An Insidious and Pervasive Component of Cardiac Risk Circulation, August 20, 2002; 106(8): 890 - 892. [Full Text] [PDF]
|
|
|
|
|
|
J. Pekkanen, A. Peters, G. Hoek, P. Tiittanen, B. Brunekreef, J. de Hartog, J. Heinrich, A. Ibald-Mulli, W. G. Kreyling, T. Lanki, et al. Particulate Air Pollution and Risk of ST-Segment Depression During Repeated Submaximal Exercise Tests Among Subjects With Coronary Heart Disease: The Exposure and Risk Assessment for Fine and Ultrafine Particles in Ambient Air (ULTRA) Study Circulation, August 20, 2002; 106(8): 933 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Glantz Air pollution as a cause of heart disease: Time for action J. Am. Coll. Cardiol., March 20, 2002; 39(6): 943 - 945. [Full Text] [PDF]
|
|
|
|
|
|
A. ZANOBETTI and J. SCHWARTZ Are Diabetics More Susceptible to the Health Effects of Airborne Particles? Am. J. Respir. Crit. Care Med., September 1, 2001; 164(5): 831 - 833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Arden Pope III Particulate air pollution, C-reactive protein, and cardiac risk Eur. Heart J., July 2, 2001; 22(14): 1149 - 1150. [PDF]
|
|