Copyright © 2001 by the European Society of Cardiology.
Comparison of the heparin coated vs the uncoated Jostent®—no influence on restenosis or clinical outcome
Department of Cardiology, University of Ulm, Ulm, Germany
revised January 16, 2001; accepted January 17, 2001
Abstract
Aims Heparin coating of stents is thought to reduce stent thrombosis and restenosis rates. However, clinical data comparing coated and uncoated stents of the same model are lacking. We compared the heparin coated (C) and the uncoated (U) version of the Jostent®stent with regard to the clinical and angiographic outcome after 6 months.
Methods and Results Provisional stenting was done in 277 patients and 306 lesions; only 40 were Benestent-II like lesions. Delivery success rate was 98·4%. Both groups (C/U: n=156/150 lesions) were comparable in clinical and procedural data. Post stenting, reference diameter (C/U: 2·68±0·56/2·66±0·53mm) and minimal lumen diameter did not differ (C/U: 2·48±0·47/2·48±0·52mm). During follow-up the rate of subacute stent thrombosis (C/U: 1·9%/1·3%) and myocardial infarction did not differ. Angiography at the 6-month follow-up (79·4%) revealed no difference in restenosis rate (C/U: 33·1%/30·3%). Risk factors for restenosis were a type B2/C lesion (P<0·02), a stented segment longer than 16mm (P<0·006) and a stent inflation pressure <14 bar (P<0·0063).
Conclusion Corline heparin coating of the Jostent®has no impact on the in-hospital complication rate, stent thrombosis or restenosis. The Jostent®design gives a high procedural success rate and satisfying result at 6 months in an everyday patient population undergoing provisional stenting.
Key Words: Stent, restenosis, heparin coating, thrombosis
f1 Correspondence: Martin Höher, MD, FESC, University of Ulm, Department of Cardiology, Robert-Koch-Straße 8, 89081 Ulm, Germany.
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