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European Heart Journal 2001 22(23):2171-2179; doi:10.1053/euhj.2001.2822
Copyright © 2001 by the European Society of Cardiology.
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Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload

L.J. Andersona, S. Holdenb, B. Davisb, E. Prescottc, C.C. Charriera, N.H. Buncea, D.N. Firmina, B. Wonkec, J. Porterb, J.M. Walkerb and D.J. Pennella,f1

a Cardiovascular MR Unit, Royal Brompton Hospital, London, U.K.
b University College Hospital, London, U.K.
c Whittington Hospital, London, U.K.

revised June 11, 2001; accepted June 13, 2001

Abstract

Aims To develop and validate a non-invasive method for measuring myocardial iron in order to allow diagnosis and treatment before overt cardiomyopathy and failure develops.

Methods and Results We have developed a new magnetic resonance T2-star (T2*) technique for the measurement of tissue iron, with validation to chemical estimation of iron in patients undergoing liver biopsy. To assess the clinical value of this technique, we subsequently correlated myocardial iron measured by this T2* technique with ventricular function in 106 patients with thalassaemia major. There was a significant, curvilinear, inverse correlation between iron concentration by biopsy and liver T2* (r=0·93,P <0·0001). Inter-study cardiac reproducibility was 5·0%. As myocardial iron increased, there was a progressive decline in ejection fraction (r=0·61, P<0·001). All patients with ventricular dysfunction had a myocardial T2* of <20ms. There was no significant correlation between myocardial T2* and the conventional parameters of iron status, serum ferritin and liver iron. Multivariate analysis of clinical parameters to predict the requirement for cardiac medication identified myocardial T2* as the most significant variable (odds ratio 0·79,P <0·002).

Conclusions Myocardial iron deposition can be reproducibly quantified using myocardial T2* and this is the most significant variable for predicting the need for ventricular dysfunction treatment. Myocardial iron content cannot be predicted from serum ferritin or liver iron, and conventional assessments of cardiac function can only detect those with advanced disease. Early intensification of iron chelation therapy, guided by this technique, should reduce mortality from this reversible cardiomyopathy.

Key Words: Cardiomyopathy, magnetic resonance imaging, heart failure and thalassaemia

f1 Correspondence: Professor D. J. Pennell, Cardiovascular MR Unit, Royal Brompton Hospital, Sydney Street, London SW3 6NP, U.K.


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