Copyright © 2002 by the European Society of Cardiology.
Hospitalization of patients with heart failure. A population-based study
a Cardiac Medicine, Imperial College School of Medicine at the National Heart & Lung Institute, London, U.K.
b MRC Biostatistics Unit, Institute of Public Health, Cambridge, U.K.
revised August 7, 2001; accepted August 15, 2001
Abstract
Aims To describe the clinical course of heart failure in a population-based sample of incident cases, and to identify factors predicting hospitalization and mortality.
Methods and Results Three hundred and thirty-two incident cases were identified over 15 months; 208 inpatients and 124 outpatients. Thirty-eight inpatients died during the first hospital admission (case fatality 18%) leaving 294 at risk of subsequent hospitalization. Over an average follow-up of 19 months, 173 cases were hospitalized on 311 occasions. Two hundred and twenty-four (72%) of these admissions were unplanned, with 51% due to worsening heart failure. One hundred and ten cases died over the same period. Cases diagnosed as an inpatient had 26 more admissions for worsening heart failure per 100 cases during follow-up (95%CI 9 to 44) compared to cases diagnosed as an outpatient, and also a higher mortality (hazard ratio 3·1 (95%CI 1·9 to 5·1)). Age was the only factor associated with an increased risk of hospitalization for worsening heart failure, but age, functional class and serum creatinine were predictive of mortality.
Conclusions New cases of heart failure are at high risk of subsequent hospitalization, especially during the first months after diagnosis. Whilst predicting which patients will be hospitalized is difficult, interventions designed to reduce hospitalizations for worsening heart failure should be targeted at elderly inpatients with a new diagnosis. Copyright 2001 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved
Key Words: Heart failure, prognosis, hospitalization, mortality, epidemiology
f1 Correspondence: Professor Martin R. Cowie, Cardiac Medicine, National Heart & Lung Institute, Imperial College School of Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, U.K.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Nishii, T. Inomata, H. Takehana, T. Naruke, T. Yanagisawa, M. Moriguchi, S. Takeda, and T. Izumi Prognostic utility of B-type natriuretic peptide assessment in stable low-risk outpatients with nonischemic cardiomyopathy after decompensated heart failure. J. Am. Coll. Cardiol., June 17, 2008; 51(24): 2329 - 2335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Goldberg, J. Ciampa, D. Lessard, T. E. Meyer, and F. A. Spencer Long-term Survival After Heart Failure: A Contemporary Population-Based Perspective Arch Intern Med, March 12, 2007; 167(5): 490 - 496. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Monastero, K. Palmer, C. Qiu, B. Winblad, and L. Fratiglioni Heterogeneity in Risk Factors for Cognitive Impairment, No Dementia: Population-Based Longitudinal Study From the Kungsholmen Project Am J Geriatr Psychiatry, January 1, 2007; 15(1): 60 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kirby Heart failure and diabetes in primary care The British Journal of Diabetes & Vascular Disease, September 1, 2006; 6(5): 220 - 228. [Abstract] [PDF]
|
|
|
|
|
|
M. Battaglia, D. Pewsner, P. Juni, M. Egger, H. C. Bucher, and L. M. Bachmann Accuracy of B-type natriuretic Peptide tests to exclude congestive heart failure: systematic review of test accuracy studies. Arch Intern Med, May 22, 2006; 166(10): 1073 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ghio, G. Magrini, A. Serio, C. Klersy, A. Fucilli, A. Ronaszeki, P. Karpati, G. Mordenti, A. Capriati, P. A. Poole-Wilson, et al. Effects of nebivolol in elderly heart failure patients with or without systolic left ventricular dysfunction: results of the SENIORS echocardiographic substudy Eur. Heart J., March 1, 2006; 27(5): 562 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Varela-Roman, L Grigorian, E Barge, P Bassante, M G de la Pena, and J R Gonzalez-Juanatey Heart failure in patients with preserved and deteriorated left ventricular ejection fraction Heart, April 1, 2005; 91(4): 489 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Zannad Acute heart failure syndromes: the 'Cinderella' of heart failure research Eur. Heart J. Suppl., April 1, 2005; 7(suppl_B): B8 - B12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M R Cowie, C Metcalfe, K F Fox, and G C Sutton N-terminal brain natriuretic peptide and subsequent hospital admission for worsening heart failure Heart, March 1, 2005; 91(3): 371 - 372. [Full Text] [PDF]
|
|
|
|
|
|
M. D. Flather, M. C. Shibata, A. J.S. Coats, D. J. Van Veldhuisen, A. Parkhomenko, J. Borbola, A. Cohen-Solal, D. Dumitrascu, R. Ferrari, P. Lechat, et al. Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS) Eur. Heart J., February 1, 2005; 26(3): 215 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Dickstein Appearances can deceive: even brave hearts can fail Eur. Heart J., July 2, 2004; 25(14): 1181 - 1182. [Full Text] [PDF]
|
|
|
|
|
|
D. Logeart, G. Thabut, P. Jourdain, C. Chavelas, P. Beyne, F. Beauvais, E. Bouvier, and A. C. Solal Predischarge B-type natriuretic peptide assay for identifying patients at high risk of re-admission after decompensated heart failure J. Am. Coll. Cardiol., February 18, 2004; 43(4): 635 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hogg, K. Swedberg, and J. McMurray Heart failure with preserved left ventricular systolic function: epidemiology, clinical characteristics, and prognosis J. Am. Coll. Cardiol., February 4, 2004; 43(3): 317 - 327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Formiga, D. Chivite, N. Manito, V. Osma, S. Miravet, and R. Pujol One-year follow-up of heart failure patients after their first admission QJM, February 1, 2004; 97(2): 81 - 86. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Struthers Should hospitals have a designated consultant with a specific interest in heart failure? QJM, December 1, 2003; 96(12): 877 - 879. [Full Text] [PDF]
|
|
|
|
 |
|
 T. Murray-Thomas and M. R Cowie Epidemiology and clinical aspects of congestive heart failure Journal of Renin-Angiotensin-Aldosterone System, September 1, 2003; 4(3): 131 - 136. [Abstract] [PDF]
|
|
|
|
|
|
H M Blackledge, J Tomlinson, and I B Squire Prognosis for patients newly admitted to hospital with heart failure: survival trends in 12 220 index admissions in Leicestershire 1993-2001 Heart, June 1, 2003; 89(6): 615 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W C Chow, R. E Lane, and M. R Cowie New pacing technologies for heart failure BMJ, May 15, 2003; 326(7398): 1073 - 1077. [Full Text] [PDF]
|
|
|
|
|
|
C Metcalfe, S.G Thompson, M.R Cowie, and L.D Sharples The use of hospital admission data as a measure of outcome in clinical studies of heart failure Eur. Heart J., January 1, 2003; 24(1): 105 - 112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mosterd and A.W. Hoes Reducing hospitalizations for heart failure Eur. Heart J., June 1, 2002; 23(11): 842 - 845. [Full Text] [PDF]
|
|