Copyright © 2003 by the European Society of Cardiology.
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LINCS: L-NAME (a NO synthase inhibitor) In the treatment of refractory Cardiogenic Shock
A prospective randomized study
a The Cardiology Department, Assaf-Harofeh Medical Center, Zerifin, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
b Department of Medicine "A", Assaf-Harofeh Medical Center, Zerifin, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
* Corresponding author. Gad Cotter M.D., The Cardiology Department, Assaf-Harofeh Medical Center, 70300 Zerifin Israel. Tel.: +972-8-9779778; fax: +972-8-9779779
E-mail address: cotterg{at}hotmail.com
Received 7 October 2002; revised 16 February 2003; accepted 13 March 2003
Aims To evaluate the effect of L-NAME (a nitric oxide syntahse inhibitor) in the treatment of refractory cardiogenic shock.
Methods and results We enrolled 30 consecutive patients with refractory cardiogenic shock (systolic blood pressure that deteriorated progressively to <100mmHg during an acute coronary syndrome despite maximal percutaneous coronary revascularization, intra aortic balloon pump, and IV dopamine, furosemide and fluids treatment for at least 1h, accompanied by signs of peripheral hypoperfusion). Patients were randomized to supportive care alone (n=15, control group) or to supportive care in addition to L-NAME (1mg/Kg bolus and 1mg/Kg/h continuous IV drip for 5h n=15).
Death at one month was 27% in the L-NAME group vs. 67% in the control group (p=0.008). Unaugmented mean arterial blood pressure at 24 h from randomization was 86±20mmHg in the L-NAME group vs. 66±13mmHg in the control group (p=0.004). Urine output increased at 24h by 135±78cc/h in the L-NAME group vs a decrease of 12±87cc/h in the control group (p<0.001). Time on IABP and time on mechanical ventilation were significantly shorter in the L-NAME group.
Conclusions The results of the present study further support our previous observation that NO synthase inhibitors are beneficial in the treatment of patients with refractory cardiogenic shock.
Key Words: Cardiogenic Shock • Nitric-Oxide • NO synthase inhibitors
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