Skip Navigation

European Heart Journal 2003 24(14):1340-1348; doi:10.1016/S0195-668X(03)00236-7
Copyright © 2003 by the European Society of Cardiology.
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in EHJ
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Izawa, H.
Right arrow Articles by Yokota, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Izawa, H.
Right arrow Articles by Yokota, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Regular Articles

Effect of Nicorandil on Left Ventricular End-Diastolic Pressure During Exercise in Patients with Hypertrophic Cardiomyopathy

Hideo Izawaa,*, Mitsunori Iwasec, Yasushi Takeichia, Fuji Somuraa, Kohzo Nagataa, Takao Nishizawab, Akiko Nodac, Toyoaki Muroharaa and Mitsuhiro Yokotab

a Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
b Department of Clinical Pathophysiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
c Nagoya University School of Health Sciences, Nagoya, Japan

* Corresponding author: Hideo Izawa, MD, PhD, Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Tel.: +81/52-744-2147; fax: +81/52-744-2977
E-mail address: izawa{at}med.nagoya-u.ac.jp

Received 10 November 2002; revised 11 February 2003; accepted 8 April 2003

Aims Impaired coronary microcirculation is thought to contribute to myocardial ischaemia, causing an abnormal increase in left ventricular end-diastolic pressure during exercise in individuals with hypertrophic cardiomyopathy. The effects of nicorandil on left ventricular end-diastolic pressure during exercise were examined in patients with this condition.

Methods and results Left ventricular pressures and dimensions were measured simultaneously during supine bicycle exercise in 23 patients with nonobstructive hypertrophic cardiomyopathy, before and after intravenous injection of either nicorandil (0.1mg/kg) or propranolol (0.15mg/kg). Exercise thallium-201 scintigraphy was also performed. Patients were grouped according to the changes in left ventricular end-diastolic pressure during exercise before treatment. Group I comprised 13 patients in whom left ventricular end-diastolic pressure increased progressively to abnormal values during exercise; group II comprised 10 patients in whom left ventricular end-diastolic pressure changed biphasically. The extents of both left ventricular hypertrophy and ischemic burden during exercise were greater in group I than in group II. Of the eight group I patients who received nicorandil, four individuals exhibited biphasic changes in left ventricular end-diastolic pressure during exercise after its administration whereas four subjects showed no such effect of the drug. Left ventricular end-diastolic pressure increased progressively during exercise after propranolol treatment in all 6 group II patients given this drug.

Conclusion Nicorandil has a salutary effect on the changes in left ventricular end-diastolic pressure during exercise in patients with hypertrophic cardiomyopathy.

Key Words: Coronary microcirculation • Exercise • Hypertrophic cardiomyopathy • Left ventricular end-diastolic pressure • Nicorandil


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in EHJ:

Nicorandil: a drug for many purposes: too good to be true?
Eric Eeckhout
EHJ 2003 24: 1282-1284. [Extract] [FREE Full Text]  



This article has been cited by other articles:


Home page
 HypertensionHome page
J. Xu, K. Nagata, K. Obata, S. Ichihara, H. Izawa, A. Noda, T. Nagasaka, M. Iwase, T. Naoe, T. Murohara, et al.
Nicorandil Promotes Myocardial Capillary and Arteriolar Growth in the Failing Heart of Dahl Salt-Sensitive Hypertensive Rats
Hypertension, October 1, 2005; 46(4): 719 - 724.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
E. Eeckhout
Nicorandil: a drug for many purposes: too good to be true?
Eur. Heart J., July 2, 2003; 24(14): 1282 - 1284.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.