Copyright © 2003 by the European Society of Cardiology.
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Association of an allelic variant of interleukin-6 with subclinical carotid atherosclerosis in an Australian community population
a Clinical Biochemistry, Western Australian Centre for Pathology and Medical Research (PathCentre), Perth, Western Australia, Australia
b Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and University College London Medical School, London, UK
c Channing Laboratory, Harvard Medical School and Brigham and Women’s Hospital, Boston, MA, USA
e Sir Charles Gairdner Hospital Campus of the Heart Research Institute of Western Australia, Perth, Western Australia, Australia
f Department of Cardiology, Sir Charles Gairdner Hospital, and School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
* Corresponding author: Caroline Chapman PhD, Department of Clinical Biochemistry, PathCentre, QE II Medical Centre, Nedlands, Western Australia, 6009. Tel.: +61-8-93461930; fax: +61-8-93463882
E-mail address: caroline.chapman{at}health.wa.gov.au
Received 26 November 2002; revised 7 May 2003; accepted 27 May 2003
Aims Atherosclerosis can be viewed as a low grade inflammatory process, and genetic polymorphisms within cytokines are candidate risk factors for the development of atherosclerosis. We examined the association of a common functional variant in the IL-6 gene with carotid intimal-medial wall thickness (IMT) and the presence of plaques in a randomly selected, cross-sectional Australian population.
Methods B-mode carotid ultrasound was performed on 1109 subjects aged 27–77 years, who were genotyped for the IL-6 polymorphism (-174G>C) and assessed for conventional cardiovascular risk factors.
Results The frequency of the IL-6 -174C allele was 0.41. Initial univariate analysis showed no association of the IL-6 -174G>C polymorphism with carotid IMT. Multivariate analysis however showed an association of the IL-6 -174C allele with increased IMT in subjects older than the median age of 53 years (P=0.005). Initial univariate analysis of the IL-6 -174G>C polymorphism and carotid plaque showed no association in the whole sample. In multivariate analysis the -174C allele was independently associated with an increased risk of carotid plaque in the whole sample (CC vs GG, OR=2.22, 95% CI=1.32 to 3.73, P=0.003).
Conclusions This study shows that the IL-6 -174G>C variant is independently associated with carotid plaque formation in the whole population and an increased carotid IMT in older subjects within a randomly selected, cross-sectional Australian population.
Key Words: Interleukin-6 • Polymorphism • Intimal-medial thickness • Carotid ultrasound • Carotid atherosclerosis
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