Copyright © 2003 by the European Society of Cardiology.
Regular Articles
Symptoms, myocardial ischaemia and quality of life in women:
Results from the NHLBI-sponsored WISE Study
a Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
b Atlanta Cardiovascular Research Institute, Atlanta, Georgia, USA
c Division of Cardiology, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA
d Division of Cardiovascular Medicine, University of Southern California, Los Angeles, USA
e Department of Medicine, Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
f Division of Cardiology, Department of Medicine, University of Florida, Gainesville, Florida, USA
g Division of Cardiology, Department of Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
h Division of Cardiology, Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
* Corresponding author: Marian B. Olson, MS, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. 15261, USA. Tel.: +1-412-624-5526; fax: +1-412-624-3775
E-mail address: olson{at}edc.gsph.pitt.edu
Received 13 December 2002; revised 12 February 2003; accepted 30 April 2003
Aims Our goal was to evaluate health-related quality of life (QOL) in women undergoing angiography for suspected ischaemia.
Methods and results QOL measurements were obtained in 406 women with chest pain symptoms in the Women’s Ischemia Syndrome Evaluation (WISE). QOL measures included a general rating (GR), Duke Activity Status Index (DASI), and the Beck Depression Inventory (BDI). Higher scores on the GR and DASI are indicative of better QOL and functioning. Higher scores on the BDI indicate more symptoms of depression. Women were stratified by the presence and absence of obstructive angiographic coronary artery disease (CAD) and by the presence and absence of myocardial ischaemia. Women with angiographic obstructive CAD had lower DASI and higher BDI scores compared to women without obstructive CAD (both P<0.05). Stratification by the presence and absence of ischaemia demonstrated that women with ischaemia had better QOL, evidenced by higher GR QOL scores and lower BDI scores (both P<0.05) than women without ischaemia. Symptoms of angina were significant independent predictors of QOL scores (P<0.001).
Conclusions Chest pain symptoms have a significant impact on health-related QOL in women undergoing coronary angiography for suspected myocardial ischaemia andare more important determinants of QOL than the underlying conditions of CAD or ischaemia.
Key Words: Quality of life • Coronary artery disease • Myocardial ischaemia • Women
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  L. J. Shaw, C. N. Bairey Merz, C. J. Pepine, S. E. Reis, V. Bittner, S. F. Kelsey, M. Olson, B. D. Johnson, S. Mankad, B. L. Sharaf, et al. Insights From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part I: Gender Differences in Traditional and Novel Risk Factors, Symptom Evaluation, and Gender-Optimized Diagnostic Strategies J. Am. Coll. Cardiol., February 7, 2006; 47(3_Suppl_S): S4 - S20. [Abstract] [Full Text] [PDF]
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C. N. Bairey Merz, L. J. Shaw, S. E. Reis, V. Bittner, S. F. Kelsey, M. Olson, B. D. Johnson, C. J. Pepine, S. Mankad, B. L. Sharaf, et al. Insights From the NHLBI-Sponsored Women's Ischemia Syndrome Evaluation (WISE) Study: Part II: Gender Differences in Presentation, Diagnosis, and Outcome With Regard to Gender-Based Pathophysiology of Atherosclerosis and Macrovascular and Microvascular Coronary Disease J. Am. Coll. Cardiol., February 7, 2006; 47(3_Suppl_S): S21 - S29. [Abstract] [Full Text] [PDF]
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