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European Heart Journal 2003 24(18):1663-1667; doi:10.1016/S0195-668X(03)00436-6
Copyright © 2003 by the European Society of Cardiology.
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Influence of endogenous oestrogens on QT interval duration1

Jean-Sébastien Hulota, Jean-Louis Démolisa, Rachel Rivièrea, Soraya Strabacha, Sophie Christin-Maitreb and Christian Funck-Brentanoa,*

a Division of Clinical Pharmacology and Clinical Investigation Center, Saint-Antoine University Hospital, Paris, France
b Department of Endocrinology, Saint-Antoine University Hospital, Paris, France

* Corresponding author. Pr Christian Funck-Brentano, Hôpital St-Antoine-CIC, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France.
E-mail address: christian.funck-brentano{at}sat.ap-hop-paris.fr

Received 10 February 2003; revised 24 June 2003; accepted 24 July 2003

Aims Women have a longer QT interval and a greater incidence of torsades de pointes than men. It has been suggested that oestrogens may influence the duration of cardiac repolarization. We thus investigated the influence of oestradiol (E2) on ventricular repolarization within the physiological concentration range of this hormone.

Methods and results We studied QT interval duration in 21 healthy women aged 18 to 35 years with regular menstrual cycle (mean duration: 29±1 days) during two periods associated with a wide range of oestradiol plasma levels: low level during menses (105±34pmol/l) and high level during the pre-ovulatory phase (750±277pmol/l). We used heart rate-independent assessment of QT. QT–RR pairs were measured over a wide range of RR intervals obtained at rest and during a sub-maximal exercise test. Using a monoexponential nonlinear curve fitting for the QT–RR relation, the QT1000msduring nadir and peak oestradiol periods was then determined for each subject. QT1000msinterval was not different between both study periods: 382.1±18.4ms at peak versus 382.2±19.4ms at nadir oestradiol level (P=0.98).

Conclusion No significant change in QT interval duration was observed within the large range of physiological E2 variations found during the menstrual cycle.

Key Words: Long-QT syndrome • Sex hormones • Torsades de pointes • Electrocardiology


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