Copyright © 2003 by the European Society of Cardiology.
Regular Articles
Effects of exercise training on conduit and resistance vessel function in treated and untreated hypercholesterolaemic subjects
a School of Human Movement and Exercise Science, The University of Western Australia, Perth, Australia
b University Department of Medicine, The University of Western Australia, Perth, Australia
c Department of Cardiology, Royal Perth Hospital, Western Australia, Perth, Australia
d Cardiac Transplant Unit, Royal Perth Hospital, Western Australia, Perth, Australia
* Correspondence to: Dr D. J. Green, University of Western Australia, Human Movement and Exercise Science, Crawley, Perth, Western Australia 6009, Australia. Tel.: +61-893802361; fax: +61-893801039
E-mail address: brevis{at}cyllene.uwa.edu.au
Received 11 February 2003; revised 26 May 2003; accepted 2 July 2003
Aims Despite the importance of both lipid metabolism and physical activity to cardiovascular health, few studies have examined the effect of exercise training on vascular function in hypercholesterolaemic humans.
Methods and results A randomized, cross-over design investigated the effect of 8 weeks of combined aerobic and resistance exercise training on conduit and resistance vessel function in 11 untreated subjects with hypercholesterolaemia and 11 subjects taking lipid-lowering medication. High-resolution vascular ultrasonography following forearm ischaemia and glyceryl trinitrate administration determined conduit vessel endothelium-dependent and independent function. Strain-gauge plethysmography, with intra-aerial infusions of acetylcholine, sodium nitroprusside and NG-monomethyl-L-arginine, determined resistance vessel function. Flow-mediated dilation and the forearm blood flow response to acetylcholine improved significantly following training in the treated subgroup (both P<0.05) but not the untreated, although the blood flow response to NG-monomethyl-L-arginine was augmented following training in the untreated subjects (P<0.05), indicating greater basal nitric oxide bioactivity. Training did not alter responsiveness to glyceryl trinitrate or sodium nitroprusside.
Conclusions Combined aerobic and resistance training improves endothelium-dependent conduit and resistance vessel function in hypercholesterolaemic subjects taking lipid-lowering medications and basal nitric oxide bioactivity in untreated hypercholesterolaemic subjects. Exercise training may provide additional cardiovascular benefits for hypercholesterolaemic patients including those taking lipid-lowering medication.
Key Words: Blood flow • Cholesterol • Endothelial function • Nitric oxide • Ultrasound • Exercise
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. E. Petersen, F. Wiesmann, L. E. Hudsmith, M. D. Robson, J. M. Francis, J. B. Selvanayagam, S. Neubauer, and K. M. Channon Functional and Structural Vascular Remodeling in Elite Rowers Assessed by Cardiovascular Magnetic Resonance J. Am. Coll. Cardiol., August 15, 2006; 48(4): 790 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Bassuk and J. E. Manson Epidemiological evidence for the role of physical activity in reducing risk of type 2 diabetes and cardiovascular disease J Appl Physiol, September 1, 2005; 99(3): 1193 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. P. Bleeker, M. Kooijman, G. A. Rongen, M. T. E. Hopman, and P. Smits Preserved contribution of nitric oxide to baseline vascular tone in deconditioned human skeletal muscle J. Physiol., June 1, 2005; 565(2): 685 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Coats and R. Wadsworth Marriage of resistance and conduit arteries breeds critical limb ischemia Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1044 - H1050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Green, W. Bilsborough, L. H. Naylor, C. Reed, J. Wright, G. O'Driscoll, and J. H. Walsh Comparison of forearm blood flow responses to incremental handgrip and cycle ergometer exercise: relative contribution of nitric oxide J. Physiol., January 15, 2005; 562(2): 617 - 628. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J Green, A. Maiorana, G. O'Driscoll, and R. Taylor Effect of exercise training on endothelium-derived nitric oxide function in humans J. Physiol., November 15, 2004; 561(1): 1 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Green, J. H. Walsh, A. Maiorana, V. Burke, R. R. Taylor, and J. G. O'Driscoll Comparison of resistance and conduit vessel nitric oxide-mediated vascular function in vivo: effects of exercise training J Appl Physiol, August 1, 2004; 97(2): 749 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Green, J. H. Walsh, A. Maiorana, M. J. Best, R. R. Taylor, and J. G. O'Driscoll Exercise-induced improvement in endothelial dysfunction is not mediated by changes in CV risk factors: pooled analysis of diverse patient populations Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2679 - H2687. [Abstract] [Full Text] [PDF]
|
|