Copyright © 2003 by the European Society of Cardiology.
Clinical research
Risk factors for cardiovascular disease in patients with periodontitis
a Department of Periodontology, Institute of Odontology, Karolinska Institutet, Huddinge, Sweden
b Department of Rheumatology, Karolinska Hospital, Stockholm, Sweden
c Department of Periodontology, Division of Specialist Dental Care, Central Hospital, Västerås, Sweden
d Division of Clinical Sciences (North), University of Sheffield, Sheffield, UK
* Corresponding author. Dr K. Buhlin, Institute of Odontology, Karolinska Institutet, Department of Periodontology, Alfred Nobels Alle 8, P.O. Box 4064, 141 04 Huddinge, Sweden. Tel.: +46-8-728-82-76; fax: +46-8-711-83-43
Received 17 June 2003; revised 3 September 2003; accepted 19 September 2003
Abstract
Aims This study compared plasma levels of established risk markers for atherosclerosis and indices of inflammation in 50 patients with severe periodontitis to those in 46 healthy cases.
Methods and results Full blood counts were performed and levels of high density lipoproteins (HDL), total cholesterol, haptoglobin, elastase, C-reactive protein (CRP), IL-6, TNF
receptor-1, -1-antitrypsin and antibodies against human heat shock protein (Hsp) 60, mycobacterial Hsp65 and oxLDL were determined. Total cholesterol levels were similar in both groups, whereas HDL levels were lower (P=0.007) and the lipid profile (total cholesterol/HDL) was consequentially higher (P=0.03) in patients. Monocyte counts were elevated (0.56 vs 0.44x109/l; P=0.002) and CRP levels were higher in patients, but TNF receptor-1 and elastase levels were not. Anti-oxLDL antibody levels were similar, as were levels of haptoglobin, IgG anti HSP60, IgA and IgG anti-Hsp65 antibodies. Levels of IgA anti-Hsp60 antibodies were lower in patients (P=0.0001). Logistic regression analysis revealed a relationship between periodontitis and HDL (OR 2.15/0.5mmol/l, P=0.02) and body mass index (OR 4.54 P=0.005)
Conclusion Serological differences in subjects with periodontitis, some of which involve established risk factors for atherosclerosis, might provide insight into the reported epidemiological association between periodontitis and cardiovascular disease.
Key Words: Atherosclerosis • Risk factors • Inflammation andperiodontitis
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in EHJ:
- Does periodontitis cause heart disease?
- Kimmo Mattila
EHJ 2003 24: 2079-2080.[Extract] [FREE Full Text]
This article has been cited by other articles:
|
|
 |
|
  P. J. Pussinen, K. Tuomisto, P. Jousilahti, A. S. Havulinna, J. Sundvall, and V. Salomaa Endotoxemia, Immune Response to Periodontal Pathogens, and Systemic Inflammation Associate With Incident Cardiovascular Disease Events Arterioscler Thromb Vasc Biol, June 1, 2007; 27(6): 1433 - 1439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Craig, P. Kotanko, A. R. Kamer, and N. W. Levin Periodontal diseases--a modifiable source of systemic inflammation for the end-stage renal disease patient on haemodialysis therapy? Nephrol. Dial. Transplant., February 1, 2007; 22(2): 312 - 315. [Full Text] [PDF]
|
|
|
|
 |
|
 O. Zschenker, T. Illies, and D. Ameis Overexpression of lysosomal Acid lipase and other proteins in atherosclerosis. J. Biochem., July 1, 2006; 140(1): 23 - 38. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-O. Soder, B. Soder, J. Nowak, and T. Jogestrand Early Carotid Atherosclerosis in Subjects With Periodontal Diseases Stroke, June 1, 2005; 36(6): 1195 - 1200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Meurman, M. Sanz, and S.-J. Janket ORAL HEALTH, ATHEROSCLEROSIS, AND CARDIOVASCULAR DISEASE Critical Reviews in Oral Biology & Medicine, November 1, 2004; 15(6): 403 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Pussinen, G. Alfthan, H. Rissanen, A. Reunanen, S. Asikainen, and P. Knekt Antibodies to Periodontal Pathogens and Stroke Risk Stroke, September 1, 2004; 35(9): 2020 - 2023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A Boyajian, S. M Otis, F. W Hall, and P. A Higginbottom Cardiovascular disease, periodontitis, and the monocyte relationship Eur. Heart J., August 1, 2004; 25(15): 1365 - 1366. [Full Text] [PDF]
|
|
|
|
|
|
K. Buhlin, A. Gustafsson, J. Frostegard, B. Klinge, and A Graham Pockley Cardiovascular disease, periodontitis and the monocyte relationship: Reply Eur. Heart J., August 1, 2004; 25(15): 1366 - 1366. [Full Text] [PDF]
|
|
|
|
|
|
K. Mattila Does periodontitis cause heart disease? Eur. Heart J., December 1, 2003; 24(23): 2079 - 2080. [Full Text] [PDF]
|
|