Association of lipoproteins with cytokines and cytokine receptors in heart failure patients: Differences between ischaemic versus idiopathic cardiomyopathy

doi:10.1016/j.ehj.2003.09.023

European Heart Journal 2003 24(24):2221-2226; doi:10.1016/j.ehj.2003.09.023
Copyright © 2003 by the European Society of Cardiology.

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Clinical research

Association of lipoproteins with cytokines and cytokine receptors in heart failure patients

Differences between ischaemic versus idiopathic cardiomyopathy

Viviane M. Conraads^a^,*, Johan M. Bosmans^a, Annemie J. Schuerwegh^b, Luc S. De Clerck^b, Chris H. Bridts^b, Floris L. Wuyts^c, Wim J. Stevens^b and Christiaan J. Vrints^a

^a Department of Cardiology, University Hospital Antwerp (UIA), Edegem, Belgium
^b Department of Immunology, University Hospital Antwerp (UIA), Edegem, Belgium
^c Department of Medical Statistics, University Hospital Antwerp (UIA), Edegem, Belgium

^* Correspondence to: Viviane Conraads, MD, PhD, Department of Cardiology, University Hospital Antwerp, Wilrijkstraat 10, 2650 Edegem, Belgium. Tel: +32 3 821 46 72; fax: +32 3 825 08 48
E-mail address: Viviane.Conraads{at}uza.uia.ac.be

Received 20 November 2002; revised 14 September 2003; accepted 19 September 2003

Abstract

Aims The observation that low total cholesterol predicted poorsurvival in patients with chronic heart failure, has questionedthe beneficial effect of lipid-lowering in this population.This study investigated the relation between lipoprotein concentrationsand the levels of interleukin (IL)-6, tumour necrosis factor(TNF)- ${alpha}$ and the soluble TNF- ${alpha}$ receptors in patients with chronicheart failure due to coronary artery disease (CAD) or idiopathicdilated cardiomyopathy (IDCM).

Methods and results Seventy-one patients with chronic heartfailure due to CAD (n=36) or IDCM (n=35) were enrolled. Plasmaconcentrations of lipoproteins, IL-6, TNF- ${alpha}$ , soluble TNF- ${alpha}$ receptor1 (sTNFR1) and 2 (sTNFR2) were measured. Total cholesterol/HDL-cholesterol(CHOL/HDL) correlated with levels of TNF- ${alpha}$ (r=0.24, P=0.035),sTNFR1 (r=0.32, P=0.008) and sTNFR2 (r=0.37, P=0.002). In theCAD group, CHOL/HDL and triglycerides (TG) correlated with sTNFR2(r=0.48, P=0.005 for CHOL/HDL, r=0.40, P=0.015 for TG). No relationwas found between lipoproteins and cytokines or sTNF- ${alpha}$ receptorsfor IDCM patients (P>0.1).

Conclusion An atherogenic lipid profile favoured the inflammatoryprocess in patients with heart failure due to CAD. No relationbetween lipoproteins and cytokines was detected in case of IDCM.

Key Words: Heart failure • Lipoproteins • Cytokines • Inflammation

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