Copyright © 2003 by the European Society of Cardiology.
Regular Articles
Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function
a Department of Cardiology and Endocrinology E, Frederiksberg University Hospital, Frederiksberg, Denmark
b Department of Cardiology P, Gentofte University Hospital, Hellerup, Denmark
c The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
* Corresponding author. Fax: +45-39-760107
E-mail address: lk{at}heart.dk
Received 3 December 2002; accepted 3 December 2002
Aims The purpose of this study was to evaluate the influence of left ventricular systolic function on the survival in a large consecutive cohort of patients hospitalized with congestive heart failure and to determine how left ventricular systolic function interacts with co-morbid conditions in terms of prognosis.
Methods and results Analysis of survival data from 5491 patients admitted for new or worsening heart failure to 34 departments of cardiology or internal medicine in Denmark from 1993–1996 was carried out. A standardized echocardiogram was available for 95% of the patients, and left ventricular systolic function was estimated using wall motion index score. Follow-up time was 5–8 years. Patients with preserved systolic function were older, more frequently female, and had less evidence of ischemia than patients with systolic dysfunction. After 1 year, 24% of the patients had died. Low wall motion index was a potent independent predictor of death (risk ratio for one unit increase, 0.60 (0.56–0.64)), and was of greater prognostic significance in younger patients and patients with a history of myocardial ischemia. However, even in patients with preserved systolic function, mortality was high (1 year mortality, 19%).
Conclusion In hospitalized heart failure patients, particularly in younger patients with ischemic heart disease, mortality risk is inversely related to left ventricular systolic function.
Key Words: Prognosis • Mortality • Ejection fraction • Myocardial infarction • Diastolic dysfunction
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Giannoni, M. Emdin, F. Bramanti, G. Iudice, D. P. Francis, A. Barsotti, M. Piepoli, and C. Passino Combined increased chemosensitivity to hypoxia and hypercapnia as a prognosticator in heart failure. J. Am. Coll. Cardiol., May 26, 2009; 53(21): 1975 - 1980. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Ngaage, M. E. Cowen, and A. R. Cale Cardiopulmonary bypass and left ventricular systolic dysfunction impacts operative mortality differently in elderly and young patients Eur. J. Cardiothorac. Surg., February 1, 2009; 35(2): 235 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Hawkins, M. C. Petrie, P. S. Jhund, G. W. Chalmers, F. G. Dunn, and J. J.V. McMurray Heart failure and chronic obstructive pulmonary disease: diagnostic pitfalls and epidemiology Eur J Heart Fail, February 1, 2009; 11(2): 130 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kjaergaard, B. K. Schaadt, J. O. Lund, and C. Hassager Prognostic importance of quantitative echocardiographic evaluation in patients suspected of first non-massive pulmonary embolism Eur J Echocardiogr, January 1, 2009; 10(1): 89 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schou, C. Torp-Pedersen, F. Gustafsson, J. Abdulla, and L. Kober Wall motion index, estimated glomerular filtration rate and mortality risk in patients with heart failure or myocardial infarction: A pooled analysis of 18,010 patients Eur J Heart Fail, July 1, 2008; 10(7): 682 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Oldenburg, A. Schmidt, B. Lamp, T. Bitter, B. G. Muntean, C. Langer, and D. Horstkotte Adaptive servoventilation improves cardiac function in patients with chronic heart failure and Cheyne-Stokes respiration Eur J Heart Fail, June 1, 2008; 10(6): 581 - 586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Pfister, H. Diedrichs, A. Schiedermair, S. Rosenkranz, M. Hellmich, E. Erdmann, and C. A. Schneider Prognostic impact of NT-proBNP and renal function in comparison to contemporary multi-marker risk scores in heart failure patients Eur J Heart Fail, March 1, 2008; 10(3): 315 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Tribouilloy, D. Rusinaru, H. Mahjoub, V. Souliere, F. Levy, M. Peltier, M. Slama, and Z. Massy Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study Eur. Heart J., February 1, 2008; 29(3): 339 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. W. Nielsen, L. Kober, and C. Torp-Pedersen Heart failure with preserved ejection fraction: dangerous, elusive, and difficult Eur. Heart J., February 1, 2008; 29(3): 285 - 287. [Full Text] [PDF]
|
|
|
|
|
|
C. Adamopoulos, F. Zannad, R. Fay, A. Mebazaa, A. Cohen-Solal, L. Guize, Y. Juilliere, and F. Alla Ejection fraction and blood pressure are important and interactive predictors of 4-week mortality in severe acute heart failure Eur J Heart Fail, September 1, 2007; 9(9): 935 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Huang, K.-L. Chien, W.-J. Chen, F.-C. Sung, H.-C. Hsu, T.-C. Su, and Y.-T. Lee Impact of heart failure and left ventricular function on long-term survival -- Report of a community-based cohort study in Taiwan Eur J Heart Fail, June 1, 2007; 9(6-7): 587 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-M. Yu, Q. Zhang, G. W.K. Yip, P.-W. Lee, L. C.C. Kum, Y.-Y. Lam, and J. W.-H. Fung Diastolic and Systolic Asynchrony in Patients With Diastolic Heart Failure: A Common But Ignored Condition J. Am. Coll. Cardiol., January 2, 2007; 49(1): 97 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Hildebrandt Systolic and nonsystolic heart failure: equally serious threats. JAMA, November 8, 2006; 296(18): 2259 - 2260. [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Owan, D. O. Hodge, R. M. Herges, S. J. Jacobsen, V. L. Roger, and M. M. Redfield Trends in prevalence and outcome of heart failure with preserved ejection fraction. N. Engl. J. Med., July 20, 2006; 355(3): 251 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Bhatia, J. V. Tu, D. S. Lee, P. C. Austin, J. Fang, A. Haouzi, Y. Gong, and P. P. Liu Outcome of heart failure with preserved ejection fraction in a population-based study. N. Engl. J. Med., July 20, 2006; 355(3): 260 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N P Nikitin, P H Loh, R de Silva, J Ghosh, O Y Khaleva, K Goode, A S Rigby, F Alamgir, A L Clark, and J G F Cleland Prognostic value of systolic mitral annular velocity measured with Doppler tissue imaging in patients with chronic heart failure caused by left ventricular systolic dysfunction Heart, June 1, 2006; 92(6): 775 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. G. Olsson, K. Swedberg, A. Ducharme, C. B. Granger, E. L. Michelson, J. J.V. McMurray, M. Puu, S. Yusuf, M. A. Pfeffer, and on behalf of the CHARM Investigators Atrial Fibrillation and Risk of Clinical Events in Chronic Heart Failure With and Without Left Ventricular Systolic Dysfunction: Results From the Candesartan in Heart failure-Assessment of Reduction in Mortality and morbidity (CHARM) Program J. Am. Coll. Cardiol., May 16, 2006; 47(10): 1997 - 2004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ahmed Association of Diastolic Dysfunction and Outcomes in Ambulatory Older Adults With Chronic Heart Failure J. Gerontol. A Biol. Sci. Med. Sci., October 1, 2005; 60(10): 1339 - 1344. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Thune, C. Carlsen, P. Buch, M. Seibaek, H. Burchardt, C. Torp-Pedersen, L. Kober, and on behalf of the DIAMOND investigators Different prognostic impact of systolic function in patients with heart failure and/or acute myocardial infarction Eur J Heart Fail, August 1, 2005; 7(5): 852 - 858. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Berry, K Hogg, J Norrie, K Stevenson, M Brett, and J McMurray Heart failure with preserved left ventricular systolic function: a hospital cohort study Heart, July 1, 2005; 91(7): 907 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Authors/Task Force Members, K. Swedberg, Writing Committee:, J. Cleland, H. Dargie, H. Drexler, F. Follath, M. Komajda, L. Tavazzi, O. A. Smiseth, et al. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology Eur. Heart J., June 1, 2005; 26(11): 1115 - 1140. [Full Text] [PDF]
|
|
|
|
|
|
A Varela-Roman, L Grigorian, E Barge, P Bassante, M G de la Pena, and J R Gonzalez-Juanatey Heart failure in patients with preserved and deteriorated left ventricular ejection fraction Heart, April 1, 2005; 91(4): 489 - 494. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Guzzetti, M. T. L. Rovere, G. D. Pinna, R. Maestri, E. Borroni, A. Porta, A. Mortara, and A. Malliani Different spectral components of 24 h heart rate variability are related to different modes of death in chronic heart failure Eur. Heart J., February 2, 2005; 26(4): 357 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gustafsson, C. B. Kragelund, C. Torp-Pedersen, M. Seibaek, H. Burchardt, D. Akkan, J. J. Thune, L. Kober, and for the DIAMOND study group Effect of obesity and being overweight on long-term mortality in congestive heart failure: influence of left ventricular systolic function Eur. Heart J., January 1, 2005; 26(1): 58 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J.V. McMurray and M. A. Pfeffer The year in heart failure J. Am. Coll. Cardiol., December 21, 2004; 44(12): 2398 - 2405. [Full Text] [PDF]
|
|
|
|
|
|
F. Gustafsson and J. M. O. Arnold Heart failure clinics and outpatient management: review of the evidence and call for quality assurance Eur. Heart J., September 2, 2004; 25(18): 1596 - 1604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.J Lenzen, W.J.M Scholte op Reimer, E Boersma, P.J.M.J Vantrimpont, F Follath, K Swedberg, J Cleland, and M Komajda Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey Eur. Heart J., July 2, 2004; 25(14): 1214 - 1220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Hogg, K. Swedberg, and J. McMurray Heart failure with preserved left ventricular systolic function: epidemiology, clinical characteristics, and prognosis J. Am. Coll. Cardiol., February 4, 2004; 43(3): 317 - 327. [Abstract] [Full Text] [PDF]
|
|