Copyright © 2004 by the European Society of Cardiology.
Clinical research
Accuracy of thin-slice computed tomography in the detection of coronary stenoses
a Department of Internal Medicine, Division of Cardiology, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy
b Department of Diagnostic Imaging, University of Rome "Tor Vergata", Viale Oxford 81, 00133 Rome, Italy
* Corresponding author. Tel./fax: +39-066788409
E-mail address: e.martuscelli{at}libero.it
Received 3 December 2003; revised 18 March 2004; accepted 24 March 2004
Abstract
Aim Our aim was to investigate the accuracy of multislice spiral computed tomography (MSCT) in the detection of significant (
50%) coronary stenosis using a scanner equipped for 16x0.625 mm collimation.
Methods In 64 patients (59 male, mean age 58±5 years) with suspected coronary artery disease, MSCT (GE Light Speed-16, collimation: 16x0.625 mm) was performed 20±5 days before coronary angiography (CAG). Only angiographic segments 1.5 mm were considered for analysis.
Results In all patients, MSCT was carried out without complications. Three patients were excluded from the analysis. Of 729 angiographic segments, 613 (84%) were judged evaluable by MSCT. Considering only the segments judged evaluable, the sensitivity was 89%, specificity 98%, positive predictive value 90%, and negative predictive value 98%. Including all segments in the analysis (evaluable and nonevaluable), sensitivity was 78%.
Conclusions Using a scanner with a collimation of 16x0.625 mm, our study confirms the potential role of MSCT in the detection of significant coronary stenosis with a sensitivity of 89% and a very high specificity (98%). Exclusion criteria and less than full evaluability of the coronary arteries must still be considered limitations of the method.
Key Words: Multislice spiral computed tomography • Coronary artery disease • Conventional coronary angiography
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L. Yang, Z. Zhang, Z. Fan, C. Xu, L. Zhao, W. Yu, and Z. Yan 64-MDCT Coronary Angiography of Patients With Atrial Fibrillation: Influence of Heart Rate on Image Quality and Efficacy in Evaluation of Coronary Artery Disease Am. J. Roentgenol., September 1, 2009; 193(3): 795 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sarwar, J. Rieber, E. A. Q. Mooyaart, S. K. Seneviratne, S. L. Houser, F. Bamberg, O. C. Raffel, R. Gupta, M. K. Kalra, H. Pien, et al. Calcified Plaque: Measurement of Area at Thin-Section Flat-Panel CT and 64-Section Multidetector CT and Comparison with Histopathologic Findings Radiology, October 1, 2008; 249(1): 301 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Bluemke, S. Achenbach, M. Budoff, T. C. Gerber, B. Gersh, L. D. Hillis, W. G. Hundley, W. J. Manning, B. F. Printz, M. Stuber, et al. Noninvasive Coronary Artery Imaging: Magnetic Resonance Angiography and Multidetector Computed Tomography Angiography: A Scientific Statement From the American Heart Association Committee on Cardiovascular Imaging and Intervention of the Council on Cardiovascular Radiology and Intervention, and the Councils on Clinical Cardiology and Cardiovascular Disease in the Young Circulation, July 29, 2008; 118(5): 586 - 606. [Full Text] [PDF]
|
|
|
|
 |
|
 W T Roberts, J J Bax, and L C Davies Cardiac CT and CT coronary angiography: technology and application Heart, June 1, 2008; 94(6): 781 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N E MANGHAT, V RACHAPALLI, R V. LINGEN, A M VEITCH, C A ROOBOTTOM, and G J MORGAN-HUGHES Imaging the heart valves using ECG-gated 64-detector row cardiac CT Br. J. Radiol., April 1, 2008; 81(964): 275 - 290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gottlieb and J. A.C. Lima Screening High-Risk Patients With Computed Tomography Angiography Circulation, March 11, 2008; 117(10): 1318 - 1332. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Prat-Gonzalez, J. Sanz, and M. J. Garcia Cardiac CT: Indications and Limitations J. Nucl. Med. Technol., March 1, 2008; 36(1): 18 - 24. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Saremi, A. Abolhoda, O. Ashikyan, J. C. Milliken, J. Narula, S. V. Gurudevan, K. Kaushal, and A. Raney Arterial Supply to Sinuatrial and Atrioventricular Nodes: Imaging with Multidetector CT Radiology, December 1, 2007; 246(1): 99 - 107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hamon, R. Morello, J. W. Riddell, and M. Hamon Coronary Arteries: Diagnostic Performance of 16- versus 64-Section Spiral CT Compared with Invasive Coronary Angiography Meta-Analysis Radiology, December 1, 2007; 245(3): 720 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Dewey, H.-P. Dubel, T. Schink, G. Baumann, and B. Hamm Head-to-head comparison of multislice computed tomography and exercise electrocardiography for diagnosis of coronary artery disease Eur. Heart J., October 2, 2007; 28(20): 2485 - 2490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Matt, H. Scheffel, S. Leschka, T. G. Flohr, B. Marincek, P. A. Kaufmann, and H. Alkadhi Dual-Source CT Coronary Angiography: Image Quality, Mean Heart Rate, and Heart Rate Variability Am. J. Roentgenol., September 1, 2007; 189(3): 567 - 573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Malagutti, K. Nieman, W. B. Meijboom, C. A.G. van Mieghem, F. Pugliese, F. Cademartiri, N. R. Mollet, E. Boersma, P. P. de Jaegere, and P. J. de Feyter Use of 64-slice CT in symptomatic patients after coronary bypass surgery: evaluation of grafts and coronary arteries Eur. Heart J., August 1, 2007; 28(15): 1879 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Mollet, F. Cademartiri, C. Van Mieghem, B. Meijboom, F. Pugliese, G. Runza, T. Baks, J. Dikkeboer, E. P. McFadden, M. P. Freericks, et al. Adjunctive value of CT coronary angiography in the diagnostic work-up of patients with typical angina pectoris Eur. Heart J., August 1, 2007; 28(15): 1872 - 1878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Vanhoenacker, M. H. Heijenbrok-Kal, R. Van Heste, I. Decramer, L. R. Van Hoe, W. Wijns, and M. G. M. Hunink Diagnostic Performance of Multidetector CT Angiography for Assessment of Coronary Artery Disease: Meta-analysis Radiology, August 1, 2007; 244(2): 419 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ferencik, D. Ropers, S. Abbara, R. C. Cury, U. Hoffmann, K. Nieman, T. J. Brady, F. Moselewski, W. G. Daniel, and S. Achenbach Diagnostic Accuracy of Image Postprocessing Methods for the Detection of Coronary Artery Stenoses by Using Multidetector CT Radiology, June 1, 2007; 243(3): 696 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Raff and J. A. Goldstein Coronary Angiography by Computed Tomography: Coronary Imaging Evolves J. Am. Coll. Cardiol., May 8, 2007; 49(18): 1830 - 1833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Di Carli and R. Hachamovitch New Technology for Noninvasive Evaluation of Coronary Artery Disease Circulation, March 20, 2007; 115(11): 1464 - 1480. [Full Text] [PDF]
|
|
|
|
|
|
S. Achenbach Computed Tomography Coronary Angiography J. Am. Coll. Cardiol., November 21, 2006; 48(10): 1919 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hamon, G. G.L. Biondi-Zoccai, P. Malagutti, P. Agostoni, R. Morello, M. Valgimigli, and M. Hamon Diagnostic Performance of Multislice Spiral Computed Tomography of Coronary Arteries as Compared With Conventional Invasive Coronary Angiography: A Meta-Analysis J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1896 - 1910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Leschka, S. Wildermuth, T. Boehm, L. Desbiolles, L. Husmann, A. Plass, P. Koepfli, T. Schepis, B. Marincek, P. A. Kaufmann, et al. Noninvasive Coronary Angiography with 64-Section CT: Effect of Average Heart Rate and Heart Rate Variability on Image Quality Radiology, November 1, 2006; 241(2): 378 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Budoff, S. Achenbach, R. S. Blumenthal, J. J. Carr, J. G. Goldin, P. Greenland, A. D. Guerci, J. A.C. Lima, D. J. Rader, G. D. Rubin, et al. Assessment of Coronary Artery Disease by Cardiac Computed Tomography: A Scientific Statement From the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology Circulation, October 17, 2006; 114(16): 1761 - 1791. [Full Text] [PDF]
|
|
|
|
|
|
M. Ferencik, R. C. Chan, S. Achenbach, J. B. Lisauskas, S. L. Houser, U. Hoffmann, S. Abbara, R. C. Cury, B. E. Bouma, G. J. Tearney, et al. Arterial Wall Imaging: Evaluation with 16-Section Multidetector CT in Blood Vessel Phantoms and ex Vivo Coronary Arteries Radiology, September 1, 2006; 240(3): 708 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Garcia, J. Lessick, M. H. K. Hoffmann, and for the CATSCAN Study Investigators Accuracy of 16-row multidetector computed tomography for the assessment of coronary artery stenosis. JAMA, July 26, 2006; 296(4): 403 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Onuma, K. Tanabe, G. Nakazawa, J. Aoki, H. Nakajima, K. Ibukuro, and K. Hara Noncardiac Findings in Cardiac Imaging With Multidetector Computed Tomography J. Am. Coll. Cardiol., July 18, 2006; 48(2): 402 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gilard, J.-C. Cornily, P.-Y. Pennec, C. Joret, G. Le Gal, J. Mansourati, J.-J. Blanc, and J. Boschat Accuracy of Multislice Computed Tomography in the Preoperative Assessment of Coronary Disease in Patients With Aortic Valve Stenosis J. Am. Coll. Cardiol., May 16, 2006; 47(10): 2020 - 2024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Hoffmann, M. Ferencik, R. C. Cury, and A. J. Pena Coronary CT Angiography J. Nucl. Med., May 1, 2006; 47(5): 797 - 806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A.S. Cordeiro and J. A.C. Lima Atherosclerotic plaque characterization by multidetector row computed tomography angiography. J. Am. Coll. Cardiol., April 18, 2006; 47(8 Suppl): C40 - C47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P M Donnelly, J D S Higginson, and P D Hanley Multidetector CT coronary angiography: have we found the holy grail of non-invasive coronary imaging? Heart, November 1, 2005; 91(11): 1385 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Gaspar, D. A. Halon, B. S. Lewis, S. Adawi, J. E. Schliamser, R. Rubinshtein, M. Y. Flugelman, and N. Peled Diagnosis of Coronary In-Stent Restenosis With Multidetector Row Spiral Computed Tomography J. Am. Coll. Cardiol., October 18, 2005; 46(8): 1573 - 1579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Mollet, F. Cademartiri, C. A.G. van Mieghem, G. Runza, E. P. McFadden, T. Baks, P. W. Serruys, G. P. Krestin, and P. J. de Feyter High-Resolution Spiral Computed Tomography Coronary Angiography in Patients Referred for Diagnostic Conventional Coronary Angiography Circulation, October 11, 2005; 112(15): 2318 - 2323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Achenbach, D. Ropers, F.-K. Pohle, D. Raaz, J. von Erffa, A. Yilmaz, G. Muschiol, and W. G. Daniel Detection of coronary artery stenoses using multi-detector CT with 16x0.75 collimation and 375 ms rotation Eur. Heart J., October 1, 2005; 26(19): 1978 - 1986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Leschka, H. Alkadhi, A. Plass, L. Desbiolles, J. Grunenfelder, B. Marincek, and S. Wildermuth Accuracy of MSCT coronary angiography with 64-slice technology: first experience Eur. Heart J., August 1, 2005; 26(15): 1482 - 1487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schmermund and R. Erbel Non-invasive computed tomographic coronary angiography: the end of the beginning Eur. Heart J., August 1, 2005; 26(15): 1451 - 1453. [Full Text] [PDF]
|
|
|
|
|
|
A Kuettner, T Beck, T Drosch, K Kettering, M Heuschmid, C Burgstahler, C D Claussen, A F Kopp, and S Schroeder Image quality and diagnostic accuracy of non-invasive coronary imaging with 16 detector slice spiral computed tomography with 188 ms temporal resolution Heart, July 1, 2005; 91(7): 938 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Garcia Noninvasive Coronary Angiography: Hype or New Paradigm? JAMA, May 25, 2005; 293(20): 2531 - 2533. [Full Text] [PDF]
|
|
|
|
|
|
A. Kuettner, T. Beck, T. Drosch, K. Kettering, M. Heuschmid, C. Burgstahler, C. D. Claussen, A. F. Kopp, and S. Schroeder Diagnostic accuracy of noninvasive coronary imaging using 16-detector slice spiral computed tomography with 188 ms temporal resolution J. Am. Coll. Cardiol., January 4, 2005; 45(1): 123 - 127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Moreno and V. Fuster The year in atherothrombosis J. Am. Coll. Cardiol., December 7, 2004; 44(11): 2099 - 2110. [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Schuijf, J. J. Bax, J. W. Jukema, H. J. Lamb, H. W. Vliegen, L. P. Salm, A. de Roos, and E. E. van der Wall Noninvasive Angiography and Assessment of Left Ventricular Function Using Multislice Computed Tomography in Patients With Type 2 Diabetes Diabetes Care, December 1, 2004; 27(12): 2905 - 2910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Martuscelli, A. Romagnoli, A. D'Eliseo, M. Tomassini, C. Razzini, M. Sperandio, G. Simonetti, F. Romeo, and J.L. Mehta Evaluation of Venous and Arterial Conduit Patency by 16-Slice Spiral Computed Tomography Circulation, November 16, 2004; 110(20): 3234 - 3238. [Abstract] [Full Text] [PDF]
|
|