Skip Navigation

European Heart Journal 2004 25(13):1139-1145; doi:10.1016/j.ehj.2004.04.036
Copyright © 2004 by the European Society of Cardiology.
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Morrow, D. A.
Right arrow Articles by Braunwald, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morrow, D. A.
Right arrow Articles by Braunwald, E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Clinical research

The Risk Score Profile: a novel approach to characterising the risk of populations enrolled in clinical studies

David A. Morrowa,*, Elliott M. Antmana, Sabina A. Murphya, Susan F. Assmannb, Robert P. Giuglianoa, Christopher P. Cannona, C. Michael Gibsona, Carolyn H. McCabea, Hal V. Barronc, Frans Van de Werfd and Eugene Braunwalda

a TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
b New England Research Institutes, Watertown, MA, USA
c Department of Medicine, University of California San Francisco and Department of Medical Affairs, Genentech, Inc, San Francisco, CA, USA
d Department of Cardiology, UH Gasthuisberg, Leuven, Belgium

Received December 21, 2003; revised April 8, 2004; accepted April 29, 2004 * Corresponding author. Tel.: +1-617-278-0145; fax: +1-617-734-7329
E-mail address: dmorrow{at}partners.org

This paper was guest edited by C. Granger, Duke University Medical Center, Durham, USA

Aims Interpreting the results and practice implications of clinical studies requires accurate characterisation of the baseline risk of the population. We evaluated the Thrombolysis in Myocardial Infarction (TIMI) risk score for STEMI as a tool to describe and compare the risk profile of populations enrolled in three clinical trials (InTIME-II, ASSENT-2 and MAGIC) and the National Registry of Myocardial Infarction.

Methods and Results The risk score was calculated for each patient and the frequency distribution plotted for each population. The Risk Score Profiles were compared using the Kolmogorov–Smirnov test. The Risk Score Profile demonstrated a striking concordance between the baseline risk of patients in InTIME-II and ASSENT-2 (median scores in each=, . In contrast, the distributions in MAGIC (designed to enroll high risk) and NRMI (registry) were shifted significantly toward higher risk (median scores= for MAGIC and in NRMI, for each vs. InTIME-II). A graded relationship between the risk score and mortality was evident in each study .

Conclusions The frequency distribution of the TIMI Risk Score, or similar tools for risk assessment, may be used to quantify and readily compare the risk profile of populations enrolled in clinical studies.

Key Words: Clinical trials • Prognosis • Myocardial infarction • Mortality • Risk factors


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CirculationHome page
J. S. Alpert
A Plethora of Prognostic Pearls
Circulation, September 23, 2008; 118(13): 1312 - 1313.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
S. D. Wiviott, D. A. Morrow, P. D. Frederick, E. M. Antman, and E. Braunwald
Application of the Thrombolysis In Myocardial Infarction Risk Index in Non-ST-Segment Elevation Myocardial Infarction: Evaluation of Patients in the National Registry of Myocardial Infarction
J. Am. Coll. Cardiol., April 18, 2006; 47(8): 1553 - 1558.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. P. Giugliano and E. Braunwald
The Year in Non--ST-Segment Elevation Acute Coronary Syndromes
J. Am. Coll. Cardiol., September 6, 2005; 46(5): 906 - 919.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.