Copyright © 2004 by the European Society of Cardiology.
Clinical research
Differences between patients with a preserved and a depressed left ventricular function: a report from the EuroHeart Failure Survey
a Department of Cardiology, Erasmus Medical Center, Thoraxcenter, Rotterdam, The Netherlands
b Department of Medicine, University Hospital Zürich, Zürich, Switzerland
c Sahlgrenska University Hospital, Göteborg, Sweden
d Department of Cardiology, University of Hull, Kingston upon Hull, UK
e Department of Cardiology, Hôpital Pitié Salpétrière, 47-83 Bld de l'Hopital, 75013 Paris, France
Received January 29, 2004;
revised June 8, 2004;
accepted June 8, 2004
* Corresponding author
E-mail address: michel.komajda{at}psl.ap-hop-paris.fr
See page 1181 for the editorial comment on this article.1
Aims Due to a lack of clinical trials, scientific evidence regarding the management of patients with chronic heart failure and preserved left ventricular function (PLVF) is scarce. The EuroHeart Failure Survey provided information on the characteristics, treatment and outcomes of patients with PLVF as compared to patients with a left ventricular systolic dysfunction (LVSD).
Methods and results We performed a secondary analysis using data from the EuroHeart Failure Survey, only including patients with a measurement of LV function 
. We selected two groups: patients with LVSD (54%) and patients with a PLVF (46%). Patients with a PLVF were, on average, 4 years older and more often women (55% vs. 29%, respectively, p <0.001) as compared to LVSD patients, and were more likely to have hypertension (59% vs. 50%, 
) and atrial fibrillation (25% vs. 23%, 
). PLVF patients received less cardiovascular medication compared to PLVF patients, with the exception of calcium antagonists. Multivariate analysis revealed that LVSD was an independent predictor for mortality, while no differences in treatment effect on mortality between the two groups was observed. A sensitivity analysis, using different thresholds to separate patients with and without LVSD revealed comparable findings.
Conclusions In the EuroHeart Failure Survey, a high percentage of heart failure patients had PLVF. Although major clinical differences were seen between the groups, morbidity and mortality was high in both groups.
Key Words: Heart failure • Preserved left ventricular function • Left ventricular systolic dysfunction • EuroHeart survey
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