Skip Navigation

European Heart Journal 2004 25(16):1428-1437; doi:10.1016/j.ehj.2004.06.013
Copyright © 2004 by the European Society of Cardiology.
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in EHJ
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Laukkanen, J. A.
Right arrow Articles by Salonen, J. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laukkanen, J. A.
Right arrow Articles by Salonen, J. T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Clinical research

The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study

Jari A. Laukkanena,b,*, Sudhir Kurla, Riitta Salonena, Rainer Rauramaac,d and Jukka T. Salonena,e,f

a Research Institute of Public Health, University of Kuopio, Kuopio, Finland
b Savonlinna Central Hospital, Savonlinna, Finland
c Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
d Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
e Department of Community Health and General Practice, University of Kuopio, Kuopio, Finland
f Ltd Jurilab Oy, Kuopio, Finland

Received January 30, 2004; revised May 28, 2004; accepted June 3, 2004 * Corresponding author. Tel.: +358-17-162960; fax: +358-17-162936 (E-mail: jariantero.laukkanen{at}uku.fi).

See page 1374 for the editorial comment on this article (doi:10.1016/j.ehj.2004.06.021)

Aims Few data exist to show if the prognostic value of peak exercise oxygen consumption (VO2peak) for fatal and non-fatal coronary events is different among men with low and high pre-test probability for cardiovascular disease (CVD). Our objective was to determine whether VO2peak could predict fatal and non-fatal cardiac events in 2361 men aged 42–60 years with and without conventional risk predictors of CVD or with documented CVD during a 13-year follow-up.

Methods and Results Maximal oxygen consumption (ml/kg/min) was measured directly by using respiratory gas exchange in a cycle ergometer exercise test. Of 204 CVD deaths, 153 were due to coronary disease and 51 were due to other CVDs. A total of 323 non-fatal coronary events occurred during the follow-up. One metabolic equivalent (MET) increment in VO2peak was related to a decreased risk of coronary death in both healthy (RR=0.82, 95% CI 0.66–0.99) and unhealthy (RR=0.72, 95% CI 0.63–0.82) men. VO2peak was predictive of non-fatal and fatal cardiac events among men with or without known risk factors. In subjects with or without common risk factors, one MET increment amounted to an average decrease of 17–29% in non-fatal and 28–51% in fatal cardiac events, after adjustment for age. VO2peak and smoking represented two strongest independent and consistent risk predictors.

Conclusions VO2peak can be used as a very powerful predictor of future fatal cardiac events beyond that predicted by many conventional risk factors. On the prognostic consideration, unfit men with unfavourable risk profiles or underlying chronic disease are the risk groups that will benefit most from preventive measures.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in EHJ:

The predictive value of cardiorespiratory fitness
Franz X. Kleber
EHJ 2004 25: 1374-1375. [Extract] [FREE Full Text]  



This article has been cited by other articles:


Home page
 StrokeHome page
A. R. Luft, R. F. Macko, L. W. Forrester, F. Villagra, F. Ivey, J. D. Sorkin, J. Whitall, S. McCombe-Waller, L. Katzel, A. P. Goldberg, et al.
Treadmill Exercise Activates Subcortical Neural Networks and Improves Walking After Stroke: A Randomized Controlled Trial
Stroke, December 1, 2008; 39(12): 3341 - 3350.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
K P Savonen, T A Lakka, J A Laukkanen, T H Rauramaa, J T Salonen, and R Rauramaa
Workload at the heart rate of 100 beats/min and mortality in middle-aged men with known or suspected coronary heart disease
Heart, April 1, 2008; 94(4): e14 - e14.
[Abstract] [Full Text] [PDF]

Home page
 Am J EpidemiolHome page
X. Sui, M. J. LaMonte, and S. N. Blair
Cardiorespiratory Fitness as a Predictor of Nonfatal Cardiovascular Events in Asymptomatic Women and Men
Am. J. Epidemiol., June 15, 2007; 165(12): 1413 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
J A Laukkanen, S Kurl, J T Salonen, T A Lakka, and R Rauramaa
Peak oxygen pulse during exercise as a predictor for coronary heart disease and all cause death
Heart, September 1, 2006; 92(9): 1219 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Mora, R. F. Redberg, A. R. Sharrett, and R. S. Blumenthal
Enhanced Risk Assessment in Asymptomatic Individuals With Exercise Testing and Framingham Risk Scores
Circulation, September 13, 2005; 112(11): 1566 - 1572.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
F. X. Kleber
The predictive value of cardiorespiratory fitness
Eur. Heart J., August 2, 2004; 25(16): 1374 - 1375.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.