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European Heart Journal 2004 25(17):1534-1541; doi:10.1016/j.ehj.2004.06.015
Copyright © 2004 by the European Society of Cardiology.
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Clinical research

Role of ß1- and ß2-adrenoceptor polymorphisms in heart failure: a case-control study

Loredana Covoloa, Umberto Gelattia, Marco Metrab,*, Savina Nodarib, Antonio Piccichèa, Natalia Pezzalib, Claudia Zania, Adriana Albertia, Francesco Donatoa, Giuseppe Nardia and Livio Dei Casb

a Cattedra di Igiene, Università   di Brescia, Italy
b Cattedra di Cardiologia, Università  di Brescia, c/o Spedali Civili, P.zza Spedali Civili 1, 25123 Brescia, Italy

Received November 4, 2003; revised May 30, 2004; accepted June 10, 2004 * Corresponding author. Tel.: +39-30-3995572; fax: +39-30-3700359 (E-mail: metramarco{at}libero.it).

BACKGROUND: We hypothesised that the polymorphisms of the genes encoding for ß1- and the ß2-adrenoceptors may have a role in the pathogenesis of heart failure (HF). We therefore compared the polymorphisms of the ß1-adrenoceptor gene (Arg389Gly), the ß2-adrenoceptor gene (Arg16Gly, Gln27Glu) and their combinations in patients with HF and normal subjects living in the same area.

METHODS AND RESULTS: A total of 256 cases with HF (left ventricular ejection fraction ⩽40%) and 230 normal subjects were enrolled. The ß1- and ß2-adrenoceptor gene polymorphisms were assessed by PCR, followed by restriction enzyme digestion. No differences were observed in the distribution of any of the three genotypes studied in patients with HF and normal subjects. An analysis of the genotype combinations showed a non-significant increase in the risk of HF associated with the Arg389Gly16Gln27 (odds ratio=1.4; 95%CI 0.5–3.6) and Arg389Gly16 Glu27 (odds ratio=1.2; 95%CI, 0.5–2.8) homozygous allele combinations.

CONCLUSION: None of the three most common polymorphisms of ß-adrenoreceptors are associated with an increased risk of HF.


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