Skip Navigation

European Heart Journal 2004 25(2):158-165; doi:10.1016/j.ehj.2003.10.023
Copyright © 2004 by the European Society of Cardiology.
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Verheye, S.
Right arrow Articles by Serruys, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Verheye, S.
Right arrow Articles by Serruys, P. W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Preclinical research

Intravascular thermography: Immediate functional and morphological vascular findings

Stefan Verheyea,b,*, Guido R.Y. De Meyera,c, Rob Kramsd, Mark M. Kockxa,e, Luc C.A. Van Dammed, Babak Mousavi Gourabid, Michiel W.M. Knaapene, Glenn Van Langenhoveb and Patrick W. Serruysd

a Cardiovascular Translational Research Institute, Antwerp, Belgium
b Department of Interventional Cardiology, Middelheim Hospital, Antwerp, Belgium
c Division of Pharmacology, University of Antwerp, Antwerp, Belgium
d Department of Cardiology, Thoraxcenter, University of Rotterdam, Rotterdam, The Netherlands
e Department of Pathology, Middelheim Hospital, Antwerp, Belgium

* Address for correspondence: Stefan Verheye, M.D., Department of Interventional Cardiology, Middelheim Hospital, Lindendreef 1, 2020 Antwerp, Belgium. Tel +32 3 280 32 55; Fax +32 3 230 65 11
E-mail address: stefan.verheye{at}pandora.be

Received 14 August 2003; revised 6 October 2003; accepted 16 October 2003

Abstract

Aim To investigate safety, feasibility, and injurious effect on endothelial cells of a thermography catheter as well as effect of flow on measured temperature in non-obstructive arteries.

Methods and results Safety and feasibility were tested in both rabbit aortas and pig coronary arteries. Evaluation of endothelial damage by the catheter (acute, 7 and 14 days) was performed in pig coronaries using Evans Blue, scanning electron microscopy (SEM) and Factor-VIII antibody and compared with normal arteries and arteries that underwent intravascular ultrasound (IVUS). The effect of flow on temperature heterogeneity was analysed both in vitro and in vivo conditions. All procedures were successful without any adverse events; intra- and inter-operator variability was low. Intracoronary use of the catheter was associated with acute but reversible de-endothelialization, paralleling the findings associated with IVUS use. Changes in flow velocities under physiologic flow conditions did not significantly influence the temperature differences measured both in vitro and in vivo; temperature heterogeneity was more pronounced in absence of flow.

Conclusion Intracoronary thermography using a dedicated catheter is safe and feasible with a similar degree of de-endothelialization as IVUS. Temperature heterogeneity remained unchanged under normal physiologic flow conditions allowing clinical use of thermography.

Key Words: Atherosclerosis • Catheters • Imaging • Plaque • IVUS


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 EuropaceHome page
J. C. Nielsen, H. Kottkamp, M. Zabel, E. Aliot, U. Kreutzer, A. Bauer, A. Schuchert, H. Neuser, B. Schumacher, H. Schmidinger, et al.
Automatic home monitoring of implantable cardioverter defibrillators
Europace, June 1, 2008; 10(6): 729 - 735.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
L. Rzeszutko, J. Legutko, G. L. Kaluza, M. Wizimirski, A. Richter, M. Chyrchel, G. Heba, J. S. Dubiel, and D. Dudek
Assessment of Culprit Plaque Temperature by Intracoronary Thermography Appears Inconclusive in Patients With Acute Coronary Syndromes
Arterioscler Thromb Vasc Biol, August 1, 2006; 26(8): 1889 - 1894.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. Madjid, J. T. Willerson, and S. W. Casscells
Intracoronary Thermography for Detection of High-Risk Vulnerable Plaques.
J. Am. Coll. Cardiol., April 18, 2006; 47(8S): C80 - C85.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
K. Toutouzas, M. Drakopoulou, J. Mitropoulos, E. Tsiamis, S. Vaina, M. Vavuranakis, V. Markou, E. Bosinakou, and C. Stefanadis
Elevated Plaque Temperature in Non-Culprit De Novo Atheromatous Lesions of Patients With Acute Coronary Syndromes
J. Am. Coll. Cardiol., January 17, 2006; 47(2): 301 - 306.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
R. Krams, S. Verheye, L. C.A. van Damme, D. Tempel, B. M. Gourabi, E. Boersma, M. M. Kockx, M. W.M. Knaapen, C. Strijder, G. van Langenhove, et al.
In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity
Eur. Heart J., October 2, 2005; 26(20): 2200 - 2205.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.