Copyright © 2004 by the European Society of Cardiology.
Clinical research
Overall alcohol intake, beer, wine, and systemic markers of inflammation in western Europe: results from three MONICA samples (Augsburg, Glasgow, Lille)
a Dept. of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert-Koch-Strasse 8, D-89081 Ulm, Germany
b The George Institute for International Health, University of Sydney, Australia
c GSF-National Research Center for Environment and Health, Institute for Epidemiology, Neuherberg, Germany
d Inserm U508, Institut Pasteur de Lille, Lille, France
e Department of Medicine, Royal Infirmary, Glasgow, UK
Received June 3, 2004; revised September 27, 2004; accepted September 30, 2004 * Corresponding author. Tel.: +49 731 500 24465; fax: +49 731 500 33872 (E-mail: wolfgang.koenig{at}medizin.uni-ulm.de).
See page 2075 for the editorial comment on this article (doi:10.1016/j.ehj.2004.09.029)
AIM: Anti-inflammatory effects of moderate alcohol consumption have been proposed to explain why moderate alcohol intake lowers coronary heart disease risk. We investigated the relationship between overall alcohol, beer or wine consumption and markers of systemic inflammation in three different geographical areas in Europe.
METHODS AND RESULTS: Cross-sectional samples, each representative of the general population from Germany, Scotland, and France (MONICA Augsburg 1994/95, 2275 men and 2186 women, 25–74 years; Glasgow MONICA 1994/95, 561/616, 25–74 years, and MONICA Lille 1994/95, 581/574, 35–64 years) were studied. Alcohol intake was assessed by standardized interview. Adjusted means of C-reactive protein (CRP), fibrinogen, white blood cell (WBC) count, plasma viscosity (PV), and albumin were calculated among categories of alcohol intake, and separately for beer or wine consumption, by multiple linear regression. Self-reported moderate daily alcohol intake up to 40 g was associated with lower concentrations of CRP, fibrinogen, PV and WBC count, compared to non-drinking and heavy drinking, even after adjustment for various potential confounders.
CONCLUSIONS: Moderate consumption of either wine or beer is associated with lower levels of systemic inflammatory markers in three different European areas, suggesting that ethanol itself might be largely responsible for the potential anti-inflammatory effects of these beverages.
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in EHJ:
- Alcohol intake and markers of inflammation
- Hugo Kesteloot
EHJ 2004 25: 2075-2076.[Extract] [FREE Full Text]
This article has been cited by other articles:
|
|
 |
|
  L. Djousse, I-M. Lee, J. E. Buring, and J. M. Gaziano Alcohol Consumption and Risk of Cardiovascular Disease and Death in Women: Potential Mediating Mechanisms Circulation, July 21, 2009; 120(3): 237 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B Panagiotakos, K. Dimakopoulou, K. Katsouyanni, T. Bellander, M. Grau, W. Koenig, T. Lanki, R. Pistelli, A. Schneider, A. Peters, et al. Mediterranean diet and inflammatory response in myocardial infarction survivors Int. J. Epidemiol., June 1, 2009; 38(3): 856 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kerr, S. Penfold, S. Zouwail, P. Thomas, and J. Begley The influence of liberal alcohol consumption on glucose metabolism in patients with type 1 diabetes: a pilot study QJM, March 1, 2009; 102(3): 169 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ruckerl, A. Peters, N. Khuseyinova, M. Andreani, W. Koenig, C. Meisinger, K. Dimakopoulou, J. Sunyer, T. Lanki, F. Nyberg, et al. Determinants of the Acute-Phase Protein C-Reactive Protein in Myocardial Infarction Survivors: The Role of Comorbidities and Environmental Factors Clin. Chem., February 1, 2009; 55(2): 322 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rohrmann, J. Linseisen, T. J. Key, M. K. Jensen, K. Overvad, N. F. Johnsen, A. Tjonneland, R. Kaaks, M. M. Bergmann, C. Weikert, et al. Alcohol Consumption and the Risk for Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1282 - 1287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Imhof, R. Blagieva, N. Marx, and W. Koenig Drinking modulates monocyte migration in healthy subjects: a randomised intervention study of water, ethanol, red wine and beer with or without alcohol Diabetes and Vascular Disease Research, March 1, 2008; 5(1): 48 - 53. [Abstract] [PDF]
|
|
|
|
 |
|
 V. G. Athyros, E. N. Liberopoulos, D. P. Mikhailidis, A. A. Papageorgiou, E. S. Ganotakis, K. Tziomalos, A. I. Kakafika, A. Karagiannis, S. Lambropoulos, and M. Elisaf Association of Drinking Pattern and Alcohol Beverage Type With the Prevalence of Metabolic Syndrome, Diabetes, Coronary Heart Disease, Stroke, and Peripheral Arterial Disease in a Mediterranean Cohort Angiology, January 1, 2008; 58(6): 689 - 697. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Sacanella, M. Vazquez-Agell, M. P. Mena, E. Antunez, J. Fernandez-Sola, J. M. Nicolas, R. M Lamuela-Raventos, E. Ros, and R. Estruch Down-regulation of adhesion molecules and other inflammatory biomarkers after moderate wine consumption in healthy women: a randomized trial Am. J. Clinical Nutrition, November 1, 2007; 86(5): 1463 - 1469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Merkle, J. Wohrle, O. Grebe, T. Nusser, M. Kunze, H. A Kestler, M. Kochs, and V. Hombach Assessment of myocardial perfusion for detection of coronary artery stenoses by steady-state, free-precession magnetic resonance first-pass imaging Heart, November 1, 2007; 93(11): 1381 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Vazquez-Agell, E. Sacanella, E. Tobias, M. Monagas, E. Antunez, R. Zamora-Ros, C. Andres-Lacueva, R. M. Lamuela-Raventos, J. Fernandez-Sola, J. M. Nicolas, et al. Inflammatory Markers of Atherosclerosis Are Decreased after Moderate Consumption of Cava (Sparkling Wine) in Men with Low Cardiovascular Risk J. Nutr., October 1, 2007; 137(10): 2279 - 2284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Lim, L. M. Morton, A. F. Subar, D. Baris, R. Stolzenberg-Solomon, M. Leitzmann, V. Kipnis, T. Mouw, L. Carroll, A. Schatzkin, et al. Alcohol, Smoking, and Body Size in Relation to Incident Hodgkin's and Non-Hodgkin's Lymphoma Risk Am. J. Epidemiol., September 15, 2007; 166(6): 697 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Kloner and S. H. Rezkalla To Drink or Not to Drink? That Is the Question Circulation, September 11, 2007; 116(11): 1306 - 1317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Opie and S. Lecour The red wine hypothesis: from concepts to protective signalling molecules Eur. Heart J., July 2, 2007; 28(14): 1683 - 1693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Gigleux, J. Gagnon, A. St-Pierre, B. Cantin, G. R. Dagenais, F. Meyer, J.-P. Despres, and B. Lamarche Moderate Alcohol Consumption Is More Cardioprotective in Men with the Metabolic Syndrome J. Nutr., December 1, 2006; 136(12): 3027 - 3032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rohrmann, J. Linseisen, H. C. Boshuizen, J. Whittaker, A. Agudo, P. Vineis, P. Boffetta, M. K. Jensen, A. Olsen, K. Overvad, et al. Ethanol Intake and Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Am. J. Epidemiol., December 1, 2006; 164(11): 1103 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Giugliano, A. Ceriello, and K. Esposito The Effects of Diet on Inflammation: Emphasis on the Metabolic Syndrome J. Am. Coll. Cardiol., August 15, 2006; 48(4): 677 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. Wright, M. S.V. Elkind, T. Rundek, B. Boden-Albala, M. C. Paik, and R. L. Sacco Alcohol Intake, Carotid Plaque, and Cognition: The Northern Manhattan Study Stroke, May 1, 2006; 37(5): 1160 - 1164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Englund Ogge, G. Brohall, C. J. Behre, C. Schmidt, and B. Fagerberg Alcohol Consumption in Relation to Metabolic Regulation, Inflammation, and Adiponectin in 64-Year-Old Caucasian Women: A population-based study with a focus on impaired glucose regulation Diabetes Care, April 1, 2006; 29(4): 908 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B Schulze, K. Hoffmann, J. E Manson, W. C Willett, J. B Meigs, C. Weikert, C. Heidemann, G. A Colditz, and F. B Hu Dietary pattern, inflammation, and incidence of type 2 diabetes in women Am. J. Clinical Nutrition, September 1, 2005; 82(3): 675 - 684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. S. Schmidt, D. J. Libon, F. Pezzetta, L. Mascitelli, G. Zuccala, E. Marzetti, R. Bernabei, M. J. Stampfer, J. H. Kang, and F. Grodstein Alcohol and Cognitive Function in Older Women N. Engl. J. Med., April 28, 2005; 352(17): 1817 - 1819. [Full Text] [PDF]
|
|
|
|
|
|
H. Kesteloot Alcohol intake and markers of inflammation Eur. Heart J., December 1, 2004; 25(23): 2075 - 2076. [Full Text] [PDF]
|
|