Skip Navigation

European Heart Journal 2004 25(23):2120-2124; doi:10.1016/j.ehj.2004.09.008
Copyright © 2004 by the European Society of Cardiology.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gustavsson, C. G.
Right arrow Articles by Agardh, C.-D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gustavsson, C. G.
Right arrow Articles by Agardh, C.-D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Clinical research

Markers of inflammation in patients with coronary artery disease are also associated with glycosylated haemoglobin A1c within the normal range

Carl Gunnar Gustavssona,* and Carl-David Agardhb

a Department of Cardiology, University Hospital MAS, SE-20502 Malmö, Sweden
b Department of Endocrinology, University Hospital MAS, SE-20502 Malmö, Sweden

Received November 21, 2003; revised July 23, 2004; accepted September 3, 2004 * Corresponding author. Tel.: +46 40 33 28 63; fax: +46 40 33 62 09 (E-mail: cg{at}gustavsson.se).

AIMS: Diabetes is a risk factor for atherosclerosis and low-degree inflammation may play a central role in both diseases. Glycosylated haemoglobin A1c (HbA1c) is an established measure of long-term glycaemic control but data on its correlation with markers of inflammation are limited, especially in patients with atherosclerotic manifestations. The aim of the present study was thus to investigate the associations between HbA1c and a panel of inflammation-sensitive parameters in patients with and without diabetes.

METHODS AND RESULTS: This single centre cross-sectional study comprised 314 consecutive subjects who underwent coronary angioplasty for stable coronary artery disease. Sixty-six patients had diabetes mellitus. Haemoglobin A1c and markers of inflammation, i.e., plasma levels of CRP, fibrinogen, and albumin, erythrocyte sedimentation rate and white blood cell count were measured. All inflammation markers were altered in a more inflammatory direction in diabetic patients. Furthermore, when non-diabetic patients with HbA1c levels within the normal range were studied separately, all inflammation-sensitive parameters except albumin correlated significantly with HbA1c.

CONCLUSION: In subjects with known coronary atherosclerosis, low-degree inflammatory activity is not only increased in diabetic patients, but also increased with increasing HbA1c in non-diabetic individuals with HbA1c within the normal range, i.e., at a pre-diabetic level of glucose metabolism derangement.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
E. Porrini, M. D. Gomez, A. Alvarez, M. Cobo, J. M. Gonzalez-Posada, L. Perez, L. Hortal, J. J. Garcia, M. Dolores Checa, A. Morales, et al.
Glycated haemoglobin levels are related to chronic subclinical inflammation in renal transplant recipients without pre-existing or new onset diabetes
Nephrol. Dial. Transplant., July 1, 2007; 22(7): 1994 - 1999.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
V. Menon, T. Greene, A. A. Pereira, X. Wang, G. J. Beck, J. W. Kusek, A. J. Collins, A. S. Levey, and M. J. Sarnak
Glycosylated Hemoglobin and Mortality in Patients with Nondiabetic Chronic Kidney Disease
J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3411 - 3417.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.