Copyright © 2004 by the European Society of Cardiology.
Preclinical research
The effects of changes in loading conditions and modulation of inotropic state on the myocardial performance index: comparison with conductance catheter measurements
Division of Cardiology, Hospital for Sick Children, 555 University Avenue, Toronto, Canada, M5G 1X8
Kinderherz-Praxis, Munich, Germany
Received 11 September 2003; revised 23 July 2004; accepted 29 July 2004 * Corresponding author. Tel.: +1 416 8136132; fax: +1 416 8137547 (E-mail: andrew.redington{at}sickkids.ca).
See page 2185 for the editorial comment on this article (doi:10.1016/j.ehj.2004.10.017)
AIM: The myocardial performance index (MPI), or Tei index, has been shown to be useful in the assessment of global myocardial performance. There are few invasive data however, which examine its load dependence or sensitivity to acute changes in contractile function. The purpose of this study was therefore to study formally the effect of clinically relevant changes in these parameters in an animal model.
METHODS AND RESULTS: We examined 10 Yorkshire pigs using echocardiographic assessment and simultaneous measurements of intraventricular pressure and volume by conductance catheterization. With dobutamine infusion, there was no significant change in the MPI (0.26±0.13–0.22±0.11; p=0.42), but dP/dtmaxincreased significantly (1001±240–1569±532 mm Hg/s, p<0.001). Afterload increase (40% change in ventricular pressure) and preload reduction (20% change in ventricular volume) were associated with significant increases in the MPI (0.26±0.13–0.49±0.20; p<0.005 and 0.26±0.13–0.51±0.20; p<0.001, respectively) without any significant change in maximal elastance (Ees).
CONCLUSIONS: The MPI, or Tei index, is significantly affected by acute changes in loading conditions but is unable to consistently detect acute changes in contractile function.
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