Skip Navigation

European Heart Journal 2004 25(3):240-245; doi:10.1016/j.ehj.2003.10.028
Copyright © 2004 by the European Society of Cardiology.
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Pollak, A.
Right arrow Articles by Dresner Pollak, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pollak, A.
Right arrow Articles by Dresner Pollak, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Clinical research

Association of oestrogen receptor alpha gene polymorphism with the angiographic extent of coronary artery disease

Arthur Pollaka,*, Ariel Rokachb, Anat Blumenfeldc, Laura J Rosend, Luba Resnike and Rivka Dresner Pollake

a Department of Cardiology, Hadassah–Hebrew University Medical Center, Jerusalem, Israel
b Department of Medicine on Mount Scopus, Hadassah–Hebrew University Medical Center, Jerusalem, Israel
c Department of Ophthalmology, Hadassah–Hebrew University Medical Center, Jerusalem, Israel
d Authority for Computation and Information (Ein Kerem Branch), Hebrew University, Jerusalem, Israel
e Endocrinology and Metabolism Service, Hadassah–Hebrew University Medical Center, Jerusalem, Israel

* Correspondence to: Arthur Pollak, MD, Department of Cardiology, Hadassah–Hebrew University Medical Center, P.O. Box 12000, 91120 Jerusalem, Israel. Tel: +972-2-6778910; Fax: +972-2-6510804
E-mail address: apollak{at}hadassah.org.il

Received 15 January 2003; revised 28 September 2003; accepted 29 October 2003

Abstract

Aims To investigate the association between sequence variants in the promoter region of the oestrogen receptor-{alpha} (ER-{alpha}) gene and the angiographic severity of coronary artery disease (CAD).

Methods and results We studied 503 subjects undergoing coronary angiography (mean age 63±12 years, 72% men, 28% women). Coronary artery disease extent was assessed by the number of: (1) major coronary vessels with >50% narrowing (NMCV); (2) coronary vessels with any narrowing (NCV); (3) narrowed coronary segments (NCS). The number of thymine and adenine dinucleotide repeats [(TA)n], 1174 base-pairs upstream exon 1, was determined by PCR. The median number of (TA)n(18) was used to categorize subjects into long, short and mixed allele genotypes. Poisson regression was used to analyse the association between genotypes and CAD extent, with age category (age <=55 vs >55), sex, risk factors and age at onset of CAD as covariates. In young subjects, (TA)nlength had a significant effect on NCS (P=0.047) and a borderline significant effect on NCV (P=0.066). Young subjects homozygous for long alleles had higher NCV and NCS compared to those homozygous for short alleles (NCV 3.7±2.4 vs 2.4±1.8, NCS 4.4±2.7 vs 3.1±2.3, respectively, P<=0.034).

Conclusion The (TA)nlength in the ER-{alpha} gene promoter region is associated with the angiographic severity of CAD in young patients.

Key Words: Oestrogen receptor-{alpha} gene polymorphism • Coronary artery disease • Risk factors • Angiography


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
I. Peter, A. Kelley-Hedgepeth, C. S. Fox, L. Adrienne Cupples, G. S. Huggins, D. E. Housman, R. H. Karas, M. E. Mendelsohn, D. Levy, and J. M. Murabito
Variation in Estrogen-Related Genes Associated with Cardiovascular Phenotypes and Circulating Estradiol, Testosterone, and Dehydroepiandrosterone Sulfate Levels
J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2779 - 2785.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
S. Domingues-Montanari, I. Subirana, M. Tomas, J. Marrugat, and M. Senti
Association between ESR2 Genetic Variants and Risk of Myocardial Infarction
Clin. Chem., July 1, 2008; 54(7): 1183 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
I. Peter, G. S. Huggins, A. M. Shearman, A. Pollak, C. H. Schmid, L. A. Cupples, S. Demissie, R. D. Patten, R. H. Karas, D. E. Housman, et al.
Age-Related Changes in Echocardiographic Measurements: Association With Variation in the Estrogen Receptor-{alpha} Gene
Hypertension, May 1, 2007; 49(5): 1000 - 1006.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
M Alevizaki, K Saltiki, A Cimponeriu, I Kanakakis, N Xita, C C Alevizaki, I Georgiou, and H-L Sarika
Severity of cardiovascular disease in postmenopausal women: associations with common estrogen receptor {alpha} polymorphic variants
Eur. J. Endocrinol., April 1, 2007; 156(4): 489 - 496.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
C-M Huang, S-F Lo, H-C Lin, M-L Chen, C-H Tsai, and F-J Tsai
Correlation of oestrogen receptor gene polymorphism with gouty arthritis.
Ann Rheum Dis, December 1, 2006; 65(12): 1673 - 1674.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
A. M. Shearman, J. A. Cooper, P. J. Kotwinski, G. J. Miller, S. E. Humphries, K. G. Ardlie, B. Jordan, K. Irenze, K. L. Lunetta, S. C. E. Schuit, et al.
Estrogen Receptor {alpha} Gene Variation Is Associated With Risk of Myocardial Infarction in More Than Seven Thousand Men From Five Cohorts
Circ. Res., March 17, 2006; 98(5): 590 - 592.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Rokach, A. Pollak, L. Rosen, Y. Friedlander, A. Blumenfeld, L. Reznik, and R. Dresner-Pollak
Estrogen Receptor {alpha} Gene Polymorphisms Are Associated with the Angiographic Extent of Coronary Artery Disease
J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6556 - 6560.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.