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European Heart Journal 2004 25(3):240-245; doi:10.1016/j.ehj.2003.10.028
Copyright © 2004 by the European Society of Cardiology.
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Clinical research

Association of oestrogen receptor alpha gene polymorphism with the angiographic extent of coronary artery disease

Arthur Pollaka,*, Ariel Rokachb, Anat Blumenfeldc, Laura J Rosend, Luba Resnike and Rivka Dresner Pollake

a Department of Cardiology, Hadassah–Hebrew University Medical Center, Jerusalem, Israel
b Department of Medicine on Mount Scopus, Hadassah–Hebrew University Medical Center, Jerusalem, Israel
c Department of Ophthalmology, Hadassah–Hebrew University Medical Center, Jerusalem, Israel
d Authority for Computation and Information (Ein Kerem Branch), Hebrew University, Jerusalem, Israel
e Endocrinology and Metabolism Service, Hadassah–Hebrew University Medical Center, Jerusalem, Israel

* Correspondence to: Arthur Pollak, MD, Department of Cardiology, Hadassah–Hebrew University Medical Center, P.O. Box 12000, 91120 Jerusalem, Israel. Tel: +972-2-6778910; Fax: +972-2-6510804
E-mail address: apollak{at}hadassah.org.il

Received 15 January 2003; revised 28 September 2003; accepted 29 October 2003

Abstract

Aims To investigate the association between sequence variants in the promoter region of the oestrogen receptor-{alpha} (ER-{alpha}) gene and the angiographic severity of coronary artery disease (CAD).

Methods and results We studied 503 subjects undergoing coronary angiography (mean age 63±12 years, 72% men, 28% women). Coronary artery disease extent was assessed by the number of: (1) major coronary vessels with >50% narrowing (NMCV); (2) coronary vessels with any narrowing (NCV); (3) narrowed coronary segments (NCS). The number of thymine and adenine dinucleotide repeats [(TA)n], 1174 base-pairs upstream exon 1, was determined by PCR. The median number of (TA)n(18) was used to categorize subjects into long, short and mixed allele genotypes. Poisson regression was used to analyse the association between genotypes and CAD extent, with age category (age <=55 vs >55), sex, risk factors and age at onset of CAD as covariates. In young subjects, (TA)nlength had a significant effect on NCS (P=0.047) and a borderline significant effect on NCV (P=0.066). Young subjects homozygous for long alleles had higher NCV and NCS compared to those homozygous for short alleles (NCV 3.7±2.4 vs 2.4±1.8, NCS 4.4±2.7 vs 3.1±2.3, respectively, P<=0.034).

Conclusion The (TA)nlength in the ER-{alpha} gene promoter region is associated with the angiographic severity of CAD in young patients.

Key Words: Oestrogen receptor-{alpha} gene polymorphism • Coronary artery disease • Risk factors • Angiography


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