Copyright © 2004 by the European Society of Cardiology.
Clinical research
Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome
a Department of Medicine, Nordland Hospital, Bodø, Norway
b Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
c Rønvik Health Center, Bodø, Norway
d Research Institute of Internal Medicine, Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
e Department of Clinical Chemistry, Rikshospitalet University Hospital, Oslo, Norway
f Department of Radiology, Nordland Hospital, Bodø, Norway
g Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
* Correspondence to: Dr K. T. Lappegard, Department of Medicine, Nordland Hospital, Prinsens gt. 164, N-8092 Bodø, Norway. Tel: +47-755 34000; Fax: +47-75534742
E-mail address: knut.lappegard{at}nlsh.no
Received 16 April 2003; revised 13 November 2003; accepted 4 December 2003
Abstract
Aims Inflammation plays an essential role in the atherosclerotic process, and chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) seem to play a pivotal role in the pathogenesis of atherosclerosis. A possible common inflammatory basis for the pathogenesis of type 2 diabetes, metabolic syndrome and atherosclerosis has been suggested. In this study we investigated the effect of physical exercise and the HMG-CoA reductase inhibitor pravastatin on peripheral markers of inflammation in subjects with the metabolic syndrome.
Methods The study was an unmasked randomized 2x2 factorial trial of 12 weeks duration.
Results In the combined exercise groups there was a significant reduction in MCP-1 and IL-8 of 48pg/ml (P=0.04) and 1.0pg/ml (P=0.007), respectively, as compared to the combined non-exercise groups. There was also a significant reduction vs baseline of 50pg/ml (33%) (P=0.002) and 0.35pg/ml (13%) (P=0.03) for MCP-1 and IL-8, respectively. Changes in MCP-1 were significantly correlated to changes in visceral fat (r=0.41, P=0.02).
Conclusion The protective effect of exercise might in part be due to suppression of the inflammatory process.
Key Words: Atherosclerosis • Chemokines • Exercise • Inflammation • Metabolic syndrome • Visceral fat
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