Copyright © 2004 by the European Society of Cardiology.
Clinical research
Exercise reduces plasma levels of the chemokines MCP-1 and IL-8 in subjects with the metabolic syndrome
a Department of Medicine, Nordland Hospital, Bodø, Norway
b Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
c Rønvik Health Center, Bodø, Norway
d Research Institute of Internal Medicine, Department of Cardiology, Rikshospitalet University Hospital, Oslo, Norway
e Department of Clinical Chemistry, Rikshospitalet University Hospital, Oslo, Norway
f Department of Radiology, Nordland Hospital, Bodø, Norway
g Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
* Correspondence to: Dr K. T. Lappegard, Department of Medicine, Nordland Hospital, Prinsens gt. 164, N-8092 Bodø, Norway. Tel: +47-755 34000; Fax: +47-75534742
E-mail address: knut.lappegard{at}nlsh.no
Received 16 April 2003; revised 13 November 2003; accepted 4 December 2003
Abstract
Aims Inflammation plays an essential role in the atherosclerotic process, and chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) seem to play a pivotal role in the pathogenesis of atherosclerosis. A possible common inflammatory basis for the pathogenesis of type 2 diabetes, metabolic syndrome and atherosclerosis has been suggested. In this study we investigated the effect of physical exercise and the HMG-CoA reductase inhibitor pravastatin on peripheral markers of inflammation in subjects with the metabolic syndrome.
Methods The study was an unmasked randomized 2x2 factorial trial of 12 weeks duration.
Results In the combined exercise groups there was a significant reduction in MCP-1 and IL-8 of 48pg/ml (P=0.04) and 1.0pg/ml (P=0.007), respectively, as compared to the combined non-exercise groups. There was also a significant reduction vs baseline of 50pg/ml (33%) (P=0.002) and 0.35pg/ml (13%) (P=0.03) for MCP-1 and IL-8, respectively. Changes in MCP-1 were significantly correlated to changes in visceral fat (r=0.41, P=0.02).
Conclusion The protective effect of exercise might in part be due to suppression of the inflammatory process.
Key Words: Atherosclerosis • Chemokines • Exercise • Inflammation • Metabolic syndrome • Visceral fat
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. P. Vieira, V. F. de Andrade, A. C. S. Duarte, A. B. G. dos Santos, T. Mauad, M. A. Martins, M. Dolhnikoff, and C. R. F. Carvalho Aerobic conditioning and allergic pulmonary inflammation in mice. II. Effects on lung vascular and parenchymal inflammation and remodeling Am J Physiol Lung Cell Mol Physiol, October 1, 2008; 295(4): L670 - L679. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Pou, J. M. Massaro, U. Hoffmann, R. S. Vasan, P. Maurovich-Horvat, M. G. Larson, J. F. Keaney Jr, J. B. Meigs, I. Lipinska, S. Kathiresan, et al. Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress: The Framingham Heart Study Circulation, September 11, 2007; 116(11): 1234 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Flynn, B. K. McFarlin, and M. M. Markofski State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training American Journal of Lifestyle Medicine, May 1, 2007; 1(3): 220 - 235. [Abstract] [PDF]
|
|
|
|
 |
|
 J. C. Frisbee, J. B. Samora, J. Peterson, and R. Bryner Exercise training blunts microvascular rarefaction in the metabolic syndrome Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2483 - H2492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Kasimay, E. Guzel, A. Gemici, A. Abdyli, A. Sulovari, F. Ercan, and B. C. Yegen Colitis-induced oxidative damage of the colon and skeletal muscle is ameliorated by regular exercise in rats: the anxiolytic role of exercise Exp Physiol, September 1, 2006; 91(5): 897 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sell, D. Dietze-Schroeder, U. Kaiser, and J. Eckel Monocyte Chemotactic Protein-1 Is a Potential Player in the Negative Cross-Talk between Adipose Tissue and Skeletal Muscle Endocrinology, May 1, 2006; 147(5): 2458 - 2467. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Herder, S. Muller-Scholze, P. Rating, W. Koenig, B. Thorand, B. Haastert, R. Holle, T. Illig, W. Rathmann, J. Seissler, et al. Systemic monocyte chemoattractant protein-1 concentrations are independent of type 2 diabetes or parameters of obesity: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4) Eur. J. Endocrinol., February 1, 2006; 154(2): 311 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Koh, S. H. Han, and M. J. Quon Inflammatory Markers and the Metabolic Syndrome: Insights From Therapeutic Interventions J. Am. Coll. Cardiol., December 6, 2005; 46(11): 1978 - 1985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E Malavazos, E. Cereda, L. Morricone, C. Coman, M. M Corsi, and B. Ambrosi Monocyte chemoattractant protein 1: a possible link between visceral adipose tissue-associated inflammation and subclinical echocardiographic abnormalities in uncomplicated obesity Eur. J. Endocrinol., December 1, 2005; 153(6): 871 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Urso, P. M. Clarkson, D. Hittel, E. P. Hoffman, and P. D. Thompson Changes in Ubiquitin Proteasome Pathway Gene Expression in Skeletal Muscle With Exercise and Statins Arterioscler. Thromb. Vasc. Biol., December 1, 2005; 25(12): 2560 - 2566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Malavazos, E. Cereda, L. Morricone, M. M. Corsi, and B. Ambrosi Monocyte Chemoattractant Protein-1 in Adipose Tissue J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 3128 - 3128. [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Nicklas, T. You, and M. Pahor Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training Can. Med. Assoc. J., April 26, 2005; 172(9): 1199 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Roberts and R. J. Barnard Effects of exercise and diet on chronic disease J Appl Physiol, January 1, 2005; 98(1): 3 - 30. [Abstract] [Full Text] [PDF]
|
|