European Heart Journal Advance Access originally published online on March 21, 2005
European Heart Journal 2005 26(10):1023-1030; doi:10.1093/eurheartj/ehi236
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Relation of N-terminal pro B-type natriuretic peptide to progression of aortic valve disease
Department of Cardiology, Kerckhoff Heart Center, Benekestraße 2-8, 61231 Bad Nauheim, Germany
Received 16 September 2004; revised 18 February 2005; accepted 24 February 2005; online publish-ahead-of-print 21 March 2005.
* Corresponding author. Tel: +49 6232 9960; fax:+49 6232 9962313. E-mail address: m.weber{at}kerckhoff-klinik.de
See page 951 for the editorial comment on this article (doi:10.1093/eurheartj/ehi216)
Aims Recently an elevation of B-type natriuretic peptide (BNP) and its N-terminal fragment (NT-proBNP) in patients with aortic stenosis (AS) and aortic regurgitation (AR) has been described. The objective of this study was to evaluate the relation of NT-proBNP values to the progression of aortic valve disease.
Methods and results One hundred and sixty-eight patients were included. NT-proBNP was elevated in patients with AS (n=109) and AR (n=37) linked to disease severity. Values for NT-proBNP, pressure gradient, and left ventricular mass were identical in patients (n=22) after previous valve replacement and in those patients with mild AS. NT-proBNP levels decreased in 86 patients after valve replacement (2292±353 vs. 785±101 pg/ml; P<0.01) but increased in 82 patients who were treated conservatively (616±120 vs. 1155±432 pg/mL; P=0.029), related to the progression of disease.
Conclusion NT-proBNP is elevated in patients with aortic valve disease linked to disease severity and decreases after successful surgical therapy but increases in conservatively treated patients. These data underline the consistent relation of NT-proBNP to severity of aortic valve disease. Therefore, NT-proBNP should be considered as a biomarker for the monitoring of disease during follow-up, but further studies are warranted.
Key Words: Natriuretic peptide • B-type natriuretic peptide • Aortic valve disease • Aortic valve replacement
CiteULike 
Connotea 
Del.icio.us What's this?
Related articles in EHJ:
- Should brain natriuretic peptides be measured in patients with aortic valve disease?
- Omid Salehian and Kwan L. Chan
EHJ 2005 26: 951-952.[Extract] [Full Text]
This article has been cited by other articles:
|
|
 |
|
  Y Allanore, K Wahbi, D Borderie, S Weber, A Kahan, and C Meune N-terminal pro-brain natriuretic peptide in systemic sclerosis: a new cornerstone of cardiovascular assessment? Ann Rheum Dis, December 1, 2009; 68(12): 1885 - 1889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. E. Coglianese and R. Davidoff Predicting Outcome in Patients With Asymptomatic Aortic Stenosis Circulation, July 7, 2009; 120(1): 9 - 11. [Full Text] [PDF]
|
|
|
|
|
|
J.-L. Monin, P. Lancellotti, M. Monchi, P. Lim, E. Weiss, L. Pierard, and P. Gueret Risk Score for Predicting Outcome in Patients With Asymptomatic Aortic Stenosis Circulation, July 7, 2009; 120(1): 69 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A L Baggish, D M Lloyd-Jones, J Blatt, A M Richards, J Lainchbury, M O'Donoghue, R Sakhuja, A A Chen, and J L Januzzi A clinical and biochemical score for mortality prediction in patients with acute dyspnoea: derivation, validation and incorporation into a bedside programme Heart, August 1, 2008; 94(8): 1032 - 1037. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R S Gabriel, A J Kerr, V Sharma, I S L Zeng, and R A H Stewart B-type natriuretic peptide and left ventricular dysfunction on exercise echocardiography in patients with chronic aortic regurgitation Heart, July 1, 2008; 94(7): 897 - 902. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Weber, M. Burian, I. Dragutinovic, H. Moellmann, H. Nef, A. Elsaesser, V. Mitrovic, C. Hamm, and G. Geisslinger Genetic polymorphism of the type A human natriuretic peptide receptor (NPR-A) gene contributes to the interindividual variability in the BNP system Eur J Heart Fail, May 1, 2008; 10(5): 482 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. El-Khuffash and E. J Molloy Are B-type natriuretic peptide (BNP) and N-terminal-pro-BNP useful in neonates? Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2007; 92(4): F320 - F324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Bergler-Klein, G. Mundigler, P. Pibarot, I. G. Burwash, J. G. Dumesnil, C. Blais, C. Fuchs, D. Mohty, R. S. Beanlands, Z. Hachicha, et al. B-Type Natriuretic Peptide in Low-Flow, Low-Gradient Aortic Stenosis: Relationship to Hemodynamics and Clinical Outcome: Results From the Multicenter Truly or Pseudo-Severe Aortic Stenosis (TOPAS) Study Circulation, June 5, 2007; 115(22): 2848 - 2855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Stout and C. M. Otto Indications for Aortic Valve Replacement in Aortic Stenosis J Intensive Care Med, January 1, 2007; 22(1): 14 - 25. [Abstract] [PDF]
|
|
|
|
|
|
M Weber, M Hausen, R Arnold, H Nef, H Moellman, A Berkowitsch, A Elsaesser, R Brandt, V Mitrovic, and C Hamm Prognostic value of N-terminal pro-B-type natriuretic peptide for conservatively and surgically treated patients with aortic valve stenosis Heart, November 1, 2006; 92(11): 1639 - 1644. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Shelton, A. L. Clark, K. Goode, A. S. Rigby, and J. G.F. Cleland The diagnostic utility of N-terminal pro-B-type natriuretic peptide for the detection of major structural heart disease in patients with atrial fibrillation Eur. Heart J., October 1, 2006; 27(19): 2353 - 2361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kolditz, M. Halank, C. S. Schiemanck, A. Schmeisser, and G. Hoffken High diagnostic accuracy of NT-proBNP for cardiac origin of pleural effusions Eur. Respir. J., July 1, 2006; 28(1): 144 - 150. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Otto Valvular Aortic Stenosis: Disease Severity and Timing of Intervention J. Am. Coll. Cardiol., June 6, 2006; 47(11): 2141 - 2151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Weber and C. Hamm Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine. Heart, June 1, 2006; 92(6): 843 - 849. [Full Text] [PDF]
|
|
|
|
|
|
N. O. Neverdal, C. W. Knudsen, T. Husebye, O. A. Vengen, J. Pepper, M. Lie, and T. Tonnessen The effect of aortic valve replacement on plasma B-type natriuretic peptide in patients with severe aortic stenosis -- one year follow-up Eur J Heart Fail, May 1, 2006; 8(3): 257 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maisel The Coming of Age of Natriuretic Peptides: The Emperor Does Have Clothes! J. Am. Coll. Cardiol., January 3, 2006; 47(1): 61 - 64. [Full Text] [PDF]
|
|
|
|
|
|
O. Salehian and K. L. Chan Should brain natriuretic peptides be measured in patients with aortic valve disease? Eur. Heart J., May 2, 2005; 26(10): 951 - 952. [Full Text] [PDF]
|
|