European Heart Journal Advance Access originally published online on February 25, 2005
European Heart Journal 2005 26(12):1196-1204; doi:10.1093/eurheartj/ehi164
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Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function
1Institute of Cardiology, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Rome, Italy
2Institute of Haematology, Catholic University of the Sacred Heart, Largo A. Gemelli 8, 00168 Rome, Italy
Received 11 August 2004; revised 5 January 2005; accepted 13 January 2005; online publish-ahead-of-print 25 February 2005.
* Corresponding author. Tel: +39 06 30154187; fax: +39 06 3055535. E-mail address: antoniomarialeone{at}libero.it
Aims Recent data suggest that the administration of bone marrow-derived stem cells (BMSC) might improve myocardial perfusion and left ventricular (LV) function after acute myocardial infarction (AMI). The aim of this study was to assess spontaneous mobilization of BMSC expressing the haematopoietic and endothelial progenitor cell-associated antigen CD34+ after AMI and its relation to post-infarction remodelling.
Methods and results Peripheral blood concentration of CD34+ BMSC was measured by flow cytometry in 54 patients with AMI, 26 patients with chronic stable angina (CSA), and 43 normal healthy subjects. In patients with AMI, LV function was measured by 2D-echocardiography. Eighteen AMI patients were reassessed at 1 year. BMSC concentration was higher in patients with AMI (mean peak value: 7.04±6.27 cells/µL), than in patients with CSA (3.80±2.12 cells/µL, P=0.036) and in healthy controls (1.87±1.52 cells/µL, P<0.001). At multivariable analysis statin use (P<0.001), primary percutaneous intervention (P=0.048) and anterior AMI (P=0.05) were the only independent predictors of increased BMSC mobilization after AMI. In the 28 patients without subsequent acute coronary events reassessed at 1 year follow-up, CD34+ cell concentration was an independent predictor of global and regional improvement of LV function (r=0.52, P=0.004 and r=–0.41, P=0.03, respectively).
Conclusion AMI is followed by enhanced spontaneous mobilization of BMSC, in particular, in patients on statin therapy and following a primary percutaneous intervention. More importantly persistent spontaneous mobilization of BMSC might contribute to determine a more favourable post-AMI remodelling.
Key Words: Myocardial infarction • Remodelling • Stem cells
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