Skip Navigation


European Heart Journal Advance Access originally published online on April 11, 2005
European Heart Journal 2005 26(12):1213-1220; doi:10.1093/eurheartj/ehi254
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
26/12/1213    most recent
ehi254v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in EHJ
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (25)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Dijk, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dijk, J. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Carotid stiffness and the risk of new vascular events in patients with manifest cardiovascular disease. The SMART study

Joke M. Dijk1, Ale Algra1,2,3, Yolanda van der Graaf1, Diederick E. Grobbee1, Michiel L. Bots1,* on behalf of the SMART study group

1Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Huispostnummer Str. 6.131, PO Box 85060, 3508 BA Utrecht, The Netherlands
2Department of Neurology, Rudolph Magnus Institute for Neuroscience, University Medical Center Utrecht,Utrecht, The Netherlands
3Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

Received 15 December 2004; revised 24 February 2005; accepted 3 March 2005; online publish-ahead-of-print 11 April 2005.

* Corresponding author. Tel: +31 30 2509352; fax: +31 30 2505485. E-mail address: m.l.bots@jc.azu.nl

See page 1152 for the editorial comment on this article (doi:10.1093/eurheartj/ehi280)

Aims To study whether arterial stiffness is related to risk of new vascular events in patients with manifest arterial disease and to examine whether this relation varies between patients who differ with respect to baseline vascular risk, arterial stiffness, or systolic blood pressure (SBP).

Methods and results The study was performed in the first consecutive 2183 patients with manifest arterial disease enrolled in the SMART study (Second Manifestations of ARTerial disease), a cohort study among patients with manifest arterial disease or cardiovascular risk factors. Common carotid distension (i.e. the change in carotid diameter in systole relative to diastole) was measured at baseline by ultrasonography. With the distension, several stiffness parameters were determined. In the entire cohort, none of the carotid artery stiffness parameters was related to the occurrence of vascular events. However, decreased stiffness was related to decreased vascular risk in subjects with low baseline SBP. The relation of carotid stiffness with vascular events did not differ between tertiles of baseline risk and carotid stiffness.

Conclusion Carotid artery stiffness is no independent risk factor for vascular events in patients with manifest arterial disease. However, in patients with low SBP, decreased carotid stiffness may indicate a decreased risk of vascular events.

Key Words: Elasticity • Cardiovascular diseases • Risk factors • Mortality • Carotid arteries


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?

Related articles in EHJ:

Arterial stiffness: intermediate or surrogate endpoint for cardiovascular events?
Stéphane Laurent
EHJ 2005 26: 1152-1154. [Extract] [Full Text]  



This article has been cited by other articles:


Home page
 HypertensionHome page
A. Redheuil, W.-C. Yu, C. O. Wu, E. Mousseaux, A. de Cesare, R. Yan, N. Kachenoura, D. Bluemke, and J. A.C. Lima
Reduced Ascending Aortic Strain and Distensibility: Earliest Manifestations of Vascular Aging in Humans
Hypertension, February 1, 2010; 55(2): 319 - 326.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. J. Blaha, M. J. Budoff, J. J. Rivera, R. Katz, D. H. O'Leary, J. F. Polak, J. Takasu, R. S. Blumenthal, and K. Nasir
Relationship of Carotid Distensibility and Thoracic Aorta Calcification: Multi-Ethnic Study of Atherosclerosis
Hypertension, December 1, 2009; 54(6): 1408 - 1415.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
A Steptoe and J Halcox
The authors' reply:
Heart, August 1, 2008; 94(8): 1075 - 1075.
[Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. Leone, P. Ducimetiere, J. Gariepy, D. Courbon, C. Tzourio, J.-F. Dartigues, K. Ritchie, A. Alperovitch, P. Amouyel, M. E. Safar, et al.
Distension of the Carotid Artery and Risk of Coronary Events: The Three-City Study
Arterioscler Thromb Vasc Biol, July 1, 2008; 28(7): 1392 - 1397.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. E. Safar and J. Blacher
Carotid versus brachial pulse pressure in elderly persons.
J. Am. Coll. Cardiol., June 24, 2008; 51(25): 2440 - 2441.
[Full Text] [PDF]

Home page
 HypertensionHome page
S. Laurent and P. Boutouyrie
Recent Advances in Arterial Stiffness and Wave Reflection in Human Hypertension
Hypertension, June 1, 2007; 49(6): 1202 - 1206.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
S. Laurent, J. Cockcroft, L. Van Bortel, P. Boutouyrie, C. Giannattasio, D. Hayoz, B. Pannier, C. Vlachopoulos, I. Wilkinson, H. Struijker-Boudier, et al.
Expert consensus document on arterial stiffness: methodological issues and clinical applications
Eur. Heart J., November 1, 2006; 27(21): 2588 - 2605.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Paini, P. Boutouyrie, D. Calvet, A.-I. Tropeano, B. Laloux, and S. Laurent
Carotid and Aortic Stiffness: Determinants of Discrepancies
Hypertension, March 1, 2006; 47(3): 371 - 376.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
S. Laurent
Arterial stiffness: intermediate or surrogate endpoint for cardiovascular events?
Eur. Heart J., June 2, 2005; 26(12): 1152 - 1154.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.