Skip Navigation


European Heart Journal Advance Access originally published online on March 1, 2005
European Heart Journal 2005 26(15):1494-1498; doi:10.1093/eurheartj/ehi173
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
26/15/1494    most recent
ehi173v1
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (29)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cavallini, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cavallini, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Impact of the elevation of biochemical markers of myocardial damage on long-term mortality after percutaneous coronary intervention: results of the CK-MB and PCI study

Claudio Cavallini1,*, Stefano Savonitto2, Roberto Violini3, Gustavo Arraiz4, Mario Plebani5, Zoran Olivari1, Paolo Rubartelli6, Salvatore Battaglia7, Luigi Niccoli8, Giuseppe Steffenino9, Diego Ardissino10 on behalf of the Italian ‘Atherosclerosis, Thrombosis, and Vascular Biology’ and ‘Society for Invasive Cardiology—GISE’ Investigators

1Ospedale Ca' Foncello, Divisione di Cardiologia, Piazza Ospedale 1, 31100 Treviso, Italy
2Department of Cardiology, Niguarda Hospital, Milan, Italy
3Department of Interventional Cardiology, San Camillo Hospital, Rome, Italy
4Astra-Zeneca Spa, Milan, Italy
5Laboratory of Clinical Chemistry, University Hospital, Padua, Italy
6Division of Cardiology, San Martino Hospital, Genoa, Italy
7Department of Interventional Cardiology, Montevergine Hospital, Avellino, Italy
8Division of Cardiology, Civil Hospital, Brescia, Italy
9Division of Cardiology, Santa Croce Hospital, Cuneo, Italy
10Division of Cardiology, Maggiore Hospital, Parma, Italy

Received 4 September 2004; revised 11 January 2005; accepted 20 January 2005; online publish-ahead-of-print 1 March 2005.

* Corresponding author. Tel: +39 0422 322767; fax: +39 0422 322662. E-mail address: clcaval{at}tin.it

Aims Retrospective studies and post hoc analyses have suggested that mild elevations in the creatine kinase-MB (CK-MB) isoenzyme following percutaneous coronary intervention (PCI) may be associated with an increased risk of death in the long term. However, this finding is still controversial, and the prognostic significance of elevations of more sensitive markers of myocardial damage, such as the cardiac troponins, has not been established. In this multicentre prospective cohort study, we evaluated the influence of post-procedural elevations of CK-MB and troponin I (cTnI) on long-term mortality.

Methods and results The CK-MB and PCI study included 3494 consecutive patients undergoing PCI from February 2000 to October 2000 in 16 Italian tertiary centres. Blood samples were collected at baseline, and at 8–12 and 18–24 h after the procedure, and were analysed in a core biochemistry laboratory. CK-MB elevation was detected in 16% of the patients, and was associated with increased 2-year mortality [7.2 vs. 3.8%; odds ratio (OR): 1.9; 95% confidence interval (CI): 1.3–2.8; P<0.001). The degree of CK-MB elevation (peak CK-MB ratio) independently predicted the risk of death (adjusted OR per unit: 1.04; 95% CI: 1.01–1.07; P=0.009). A cTnI elevation was detected in 44.2% of the cases and was not associated with a significant increase in mortality (4.9 vs. 4.0%; OR: 1.2; 95% CI: 0.9–1.7; P=0.2).

Conclusion Post-procedural elevations of CK-MB, but not cTnI, influence 2-year mortality.

Key Words: Angioplasty • Stents • Complications • Enzymes • Prognosis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Eur Heart JHome page
R. Mehran, S. J. Pocock, G. W. Stone, T. C. Clayton, G. D. Dangas, F. Feit, S. V. Manoukian, E. Nikolsky, A. J. Lansky, A. Kirtane, et al.
Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes: a risk model from the ACUITY trial
Eur. Heart J., June 2, 2009; 30(12): 1457 - 1466.
[Abstract] [Full Text] [PDF]

Home page
 Circ Cardiovasc InterventHome page
A. Prasad, C. S. Rihal, R. J. Lennon, M. Singh, A. S. Jaffe, and D. R. Holmes Jr
Significance of Periprocedural Myonecrosis on Outcomes After Percutaneous Coronary Intervention: An Analysis of Preintervention and Postintervention Troponin T Levels in 5487 Patients
Circ Cardiovasc Intervent, August 1, 2008; 1(1): 10 - 19.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
T. Y. Wang, E. D. Peterson, D. Dai, H. V. Anderson, S. V. Rao, R. G. Brindis, M. T. Roe, and on behalf of the National Cardiovascular Data Regi
Patterns of Cardiac Marker Surveillance After Elective Percutaneous Coronary Intervention and Implications for the Use of Periprocedural Myocardial Infarction as a Quality Metric: A Report From the National Cardiovascular Data Registry (NCDR)
J. Am. Coll. Cardiol., May 27, 2008; 51(21): 2068 - 2074.
[Full Text] [PDF]

Home page
 HeartHome page
P. Schiano and P. Gabriel Steg
Measurement and prevention of myocardial injury during percutaneous coronary intervention
Heart, June 1, 2007; 93(6): 656 - 657.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
P. G. Camici and F. Crea
Coronary Microvascular Dysfunction
N. Engl. J. Med., February 22, 2007; 356(8): 830 - 840.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
C.-H. Lee, A. Low, B.-C. Tai, M. Co, M. Y. Chan, J. Lim, Y.-T. Lim, and H.-C. Tan
Pretreatment with intracoronary adenosine reduces the incidence of myonecrosis after non-urgent percutaneous coronary intervention: a prospective randomized study
Eur. Heart J., January 1, 2007; 28(1): 19 - 25.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
A. Prasad, M. Singh, A. Lerman, R. J. Lennon, D. R. Holmes Jr, and C. S. Rihal
Isolated Elevation in Troponin T After Percutaneous Coronary Intervention Is Associated With Higher Long-Term Mortality
J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1765 - 1770.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
W. Hochholzer, D. Trenk, H.-P. Bestehorn, B. Fischer, C. M. Valina, M. Ferenc, M. Gick, A. Caputo, H. J. Buttner, and F.-J. Neumann
Impact of the Degree of Peri-Interventional Platelet Inhibition After Loading With Clopidogrel on Early Clinical Outcome of Elective Coronary Stent Placement
J. Am. Coll. Cardiol., November 7, 2006; 48(9): 1742 - 1750.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
V. Balian, M. Galli, C. Marcassa, G. Cecchin, M. Child, F. Barlocco, E. Petrucci, G. Filippini, R. Michi, and M. Onofri
Intracoronary ST-Segment Shift Soon After Elective Percutaneous Coronary Intervention Accurately Predicts Periprocedural Myocardial Injury
Circulation, October 31, 2006; 114(18): 1948 - 1954.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
W. L. Miller, K. N. Garratt, M. F. Burritt, R. J. Lennon, G. S. Reeder, and A. S. Jaffe
Baseline troponin level: key to understanding the importance of post-PCI troponin elevations
Eur. Heart J., May 1, 2006; 27(9): 1061 - 1069.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
J. Herrmann
Peri-procedural myocardial injury: 2005 update
Eur. Heart J., December 1, 2005; 26(23): 2493 - 2519.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
L. Bolognese, G. Falsini, F. Liistro, and P. Angioli
Myocardial damage during percutaneous interventions for non-ST-elevation acute coronary syndromes
Eur. Heart J. Suppl., October 1, 2005; 7(suppl_K): K15 - K18.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. P. Giugliano and E. Braunwald
The Year in Non--ST-Segment Elevation Acute Coronary Syndromes
J. Am. Coll. Cardiol., September 6, 2005; 46(5): 906 - 919.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.