Skip Navigation


European Heart Journal Advance Access originally published online on April 8, 2005
European Heart Journal 2005 26(16):1660-1665; doi:10.1093/eurheartj/ehi198
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
26/16/1660    most recent
ehi198v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Fiane, A. E.
Right arrow Articles by Mollnes, T. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fiane, A. E.
Right arrow Articles by Mollnes, T. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oupjournals.org

Low mannose-binding lectin and increased complement activation correlate to allograft vasculopathy, ischaemia, and rejection after human heart transplantation

Arnt E. Fiane1, Thor Ueland2, Svein Simonsen3, Helge Scott4, Knut Endresen3, Lars Gullestad3, Odd R. Geiran1, Guttorm Haraldsen4, Lars Heggelund2, Arne K. Andreassen3, Ragnhild Wergeland5, Stig Frøland6, Pa°l Aukrust6 and Tom E. Mollnes7,*

1Department of Thoracic and Cardiovascular Surgery, Rikshospitalet University Hospital, N-0027 Oslo, Norway
2Research Institute for Internal Medicine, Rikshospitalet University Hospital, N-0027 Oslo, Norway
3Department of Cardiology, Rikshospitalet University Hospital, N-0027 Oslo, Norway
4Department of Pathology, Rikshospitalet University Hospital, N-0027 Oslo, Norway
5Department of Clinical Chemistry, Rikshospitalet University Hospital, N-0027 Oslo, Norway
6Section of Clinical Immunology and Infection Diseases, Medical Department, Rikshospitalet University Hospital, N-0027 Oslo, Norway
7Institute of Immunology, Rikshospitalet University Hospital, N-0027 Oslo, Norway

Received 30 April 2004; revised 31 January 2005; accepted 3 February 2005; online publish-ahead-of-print 8 April 2005.

* Corresponding author. Tel: +47 90630015; fax: +47 23073510. E-mail address: t.e.mollnes{at}labmed.uio.no

Aims Transplant-associated coronary artery disease (TxCAD) is a major cause of post-transplant graft failure. The aim of this study was to investigate a possible role of mannose-binding lectin (MBL) deficiency and complement activation in TxCAD.

Methods and results In a prospective study of heart transplant recipients (n=38) with a follow-up of 5.3±1.3 years (range: 0.9–6.6), angiographically verified TxCAD (n=6) was correlated to plasma MBL, complement activation, and endothelial activation (soluble E-selectin). MBL deficiency (<100 ng/mL) was detected in 3/6 patients with TxCAD and in 3/32 with non-TxCAD (Kaplan–Meier, P=0.020). Furthermore, one or more acute rejection episodes were observed in 6/6 of the MBL-deficient patients and in 15/32 of the MBL-sufficient patients ({chi}2; P=0.016). Complement activation (C4bc) correlated with soluble E-selectin (r=0.36; P=0.027), both being significantly higher in patients with ischaemia detected in the first biopsy (C4bc: 13.4±6.1 AU/mL; E-selectin: 96±13 ng/mL) than in those without ischaemia (C4bc: 6.3±0.5; E-selectin: 51±6; P=0.037 and 0.002). Finally, terminal complement complex correlated closely with mortality (P=0.002).

Conclusion Low MBL was related to the development of TxCAD and acute rejection and increased complement activation correlated to histopathologic ischaemia and mortality after heart transplantation.

Key Words: Transplant-associated coronary artery disease • Ischaemia-reperfusion • Graft rejection • Complement • Mannose-binding lectin • Soluble E-selectin


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
J. Hjelmesaeth, T. Ueland, A. Flyvbjerg, J. Bollerslev, T. Leivestad, T. Jenssen, T. K. Hansen, S. Thiel, S. Sagedal, J. Roislien, et al.
Early Posttransplant Serum Osteoprotegerin Levels Predict Long-Term (8-Year) Patient Survival and Cardiovascular Death in Renal Transplant Patients
J. Am. Soc. Nephrol., June 1, 2006; 17(6): 1746 - 1754.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.