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European Heart Journal Advance Access originally published online on May 23, 2005
European Heart Journal 2005 26(19):1945-1955; doi:10.1093/eurheartj/ehi333
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis

Arnold G. Herman1,* and Salvador Moncada2

1Division of Pharmacology, University of Antwerpen, Campus Drie Eiken, Wilrijk, B-2610 Antwerpen, Belgium
2Wolfson Institute for Biomedical Research, University College London, The Cruciform Building, Gower Street, London WC1E 6BT, UK

Received 25 February 2005; revised 18 April 2005; accepted 22 April 2005; online publish-ahead-of-print 23 May 2005.

* Corresponding author. Tel: +32 3 820 27 01.E-mail address: arnold.herman{at}ua.ac.be

Well-known risk factors for atherosclerosis include hypercholesterolaemia, hypertension, diabetes, and smoking. These conditions are associated with endothelial dysfunction, which itself is associated with reduced endothelial generation of nitric oxide (NO). This is an overview of the implications of NO generation in atherosclerosis and of the potential therapeutic benefit of drugs which donate NO, such as organic nitrates, nicorandil, and sydnonimines, or those which increase the availability of endogenous NO, such as statins, angiotensin-converting enzyme inhibitors, L-arginine, and tetrahydrobiopterin.

Key Words: Nitric oxide • Atherosclerosis • Nitric oxide donor


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