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European Heart Journal Advance Access originally published online on April 27, 2005
European Heart Journal 2005 26(19):1971-1977; doi:10.1093/eurheartj/ehi293
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Early eptifibatide improves TIMI 3 patency before primary percutaneous coronary intervention for acute ST elevation myocardial infarction: results of the randomized integrilin in acute myocardial infarction (INTAMI) pilot trial

Uwe Zeymer1,*, Ralf Zahn1, Rudolf Schiele1, Wolfgang Jansen2, Ernst Girth3, Anselm Gitt1, Karlheinz Seidl1, Rolf Schröder4, Steffen Schneider1 and Jochen Senges1

1Herzzentrum Ludwigshafen, Bremserstrasse 79, D-67063 Ludwigshafen, Germany
2Medizinische Klinik I, Klinikum Leverkusen, Germany
3Medizinische Klinik II, Klinikum Offenbach, Germany
4Universitätsklinikum Benjamin Franklin, Berlin, Germany

Received 9 December 2004; revised 17 March 2005; accepted 24 March 2005; online publish-ahead-of-print 27 April 2005.

* Corresponding author. Tel: +49 621 503 4045; fax: +49 621 503 4002. E-mail address: uwe.zeymer{at}t-online.de

Aims Adjunctive therapy with glycoprotein IIb/IIIa inhibitors has been shown to reduce ischaemic complications and improve clinical outcome in patients with primary percutaneous coronary intervention (PCI) for acute ST elevation myocardial infarction. Little is known about the use of eptifibatide in this setting.

Methods and results One hundred and two patients with ST elevation myocardial infarction <12 h scheduled for primary percutaneous intervention were randomly assigned to early eptifibatide given in the emergency room (early) or optional eptifibatide at the time of PCI (late or no). Primary endpoint was the patency of the infarct vessel before PCI. Patients in the early group received their first eptifibatide bolus, a mean of 45 min before angiography. TIMI 3 patency before PCI was observed in 34% in the early group and 10% in late or no group (P=0.01). The incidence of complete ST resolution 1 h after PCI was 61% in early group and 66% in the late or no group, respectively (P=n.s.). There were no significant differences in the rates of TIMI 3 flow after PCI, death, reinfarction, stroke, and major bleeding complications until day 30.

Conclusion In this pilot trial, double bolus eptifibatide given in the emergency room improved TIMI 3 grade flow of the infarct-related coronary artery before PCI. These results should be confirmed in a larger trial and whether this advantage translates into an improvement in clinical outcome should be tested in a trial with primary clinical endpoints.

Key Words: Acute myocardial infarction • Primary percutaneous coronary intervention • Eptifibatide • Patency


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